Literature DB >> 6438533

Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.

K A Ritchie, R L Brinster, U Storb.   

Abstract

Hybridomas were produced from spleen cells of kappa transgenic mice to investigate expression of the transgenic kappa gene, its effect on allelic exclusion and its effect on the control of light-chain gene rearrangement and expression. Our results show that the transgene is expressed normally and that the production of a complete immunoglobulin molecule turns off light-chain gene rearrangement.

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Year:  1984        PMID： 6438533     DOI： 10.1038/312517a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  47 in total

Review 1.  Receptor selection in B and T lymphocytes.

Authors:  D Nemazee
Journal:  Annu Rev Immunol       Date:  2000       Impact factor: 28.527

2.  Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras.

Authors:  A C Shaw; W Swat; L Davidson; F W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

3.  The importance of the 3'-enhancer region in immunoglobulin kappa gene expression.

Authors:  K B Meyer; M J Sharpe; M A Surani; M S Neuberger
Journal:  Nucleic Acids Res       Date:  1990-10-11       Impact factor: 16.971

Review 4.  Allelic exclusion of immunoglobulin genes: models and mechanisms.

Authors:  Christian Vettermann; Mark S Schlissel
Journal:  Immunol Rev       Date:  2010-09       Impact factor: 12.988

Review 5.  Transgenic regulation in laboratory animals.

Authors:  S Rusconi
Journal:  Experientia       Date:  1991-09-15

6.  Genes encoding the T-cell receptor alpha and beta subunits are transcribed in an ordered manner during intrathymic ontogeny.

Authors:  H D Royer; D Ramarli; O Acuto; T J Campen; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

7.  Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes.

Authors:  U Braun; K Rajewsky; R Pelanda
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-20       Impact factor: 11.205

8.  Expression of T-cell receptor alpha-chain genes in transgenic mice.

Authors:  L J Berg; B Fazekas de St Groth; F Ivars; C C Goodnow; S Gilfillan; H J Garchon; M M Davis
Journal:  Mol Cell Biol       Date:  1988-12       Impact factor: 4.272

9.  Increasing the chemical potential of the germ-line antibody repertoire.

Authors:  N Sarvetnick; D Gurushanthaiah; N Han; J Prudent; P Schultz; R Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205

10.  A foreign dihydrofolate reductase gene in transgenic mice acts as a dominant mutation.

Authors:  J W Gordon
Journal:  Mol Cell Biol       Date:  1986-06       Impact factor: 4.272
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