Literature DB >> 6437705

Gonadotrophin responses to GnRH in precocious puberty treated with GnRH analogue.

M D Donaldson, R Stanhope, T J Lee, D A Price, C G Brook, D C Savage.   

Abstract

The gonadotrophin releasing hormone analogue Buserelin was given by intranasal spray to 13 children with precocious puberty. The LH responses to GnRH reverted to prepubertal levels in the boys on 200-400 micrograms daily of the analogue while doses of 400-1200 micrograms daily were needed to suppress the girls. The significance of this apparent sex difference is uncertain.

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Year:  1984        PMID： 6437705     DOI： 10.1111/j.1365-2265.1984.tb01387.x

Source DB:  PubMed          Journal:  Clin Endocrinol (Oxf)        ISSN： 0300-0664            Impact factor:   3.478


  8 in total

Review 1.  Buserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical profile.

Authors:  R N Brogden; M M Buckley; A Ward
Journal:  Drugs       Date:  1990-03       Impact factor: 9.546

2.  Reversible inhibition of central precocious puberty with a long acting GnRH analogue.

Authors:  P S Ward; I Ward; A W McNinch; D C Savage
Journal:  Arch Dis Child       Date:  1985-09       Impact factor: 3.791

Review 3.  Luteinizing hormone-releasing hormone and its analogues: a review of biological properties and clinical uses.

Authors:  B J Furr; J R Woodburn
Journal:  J Endocrinol Invest       Date:  1988 Jul-Aug       Impact factor: 4.256

4.  The effect of treatment with an LH-RH agonist (Buserelin) on gonadal activity growth and bone maturation in children with central precocious puberty.

Authors:  S L Drop; R J Odink; C Rouwé; B J Otten; M W Van Maarschalkerweerd; M Gons; A Bot; M Meradji; F H de Jong; F M Slijper
Journal:  Eur J Pediatr       Date:  1987-05       Impact factor: 3.183

5.  Efficacy of Zoladex LA (goserelin) in the treatment of girls with central precocious or early puberty.

Authors:  W F Paterson; E McNeill; S Reid; A S Hollman; M D Donaldson
Journal:  Arch Dis Child       Date:  1998-10       Impact factor: 3.791

6.  Long-term treatment of central precocious puberty with an intranasal LHRH analogue: control of pituitary function by urinary gonadotropins.

Authors:  J L Rime; U Zumsteg; A Blumberg; F Hadziselimovic; J Girard; R P Zurbrügg
Journal:  Eur J Pediatr       Date:  1988-04       Impact factor: 3.183

7.  Sexual precocity: sex incidence and aetiology.

Authors:  N A Bridges; J A Christopher; P C Hindmarsh; C G Brook
Journal:  Arch Dis Child       Date:  1994-02       Impact factor: 3.791

8.  Ovarian ultrasound assessment in normal children, idiopathic precocious puberty, and during low dose pulsatile gonadotrophin releasing hormone treatment of hypogonadotrophic hypogonadism.

Authors:  R Stanhope; J Adams; H S Jacobs; C G Brook
Journal:  Arch Dis Child       Date:  1985-02       Impact factor: 3.791
  8 in total

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