Literature DB >> 6437694

Effect of D,L-alpha-difluoromethylornithine on murine mammary carcinogenesis.

H J Thompson, E J Herbst, L D Meeker, R Minocha, A M Ronan, R Fite.   

Abstract

The development of chemically-induced mammary gland carcinomas in rats was dramatically suppressed by provision of a 1% solution of D,L-alpha-difluoromethylornithine (DFMO) in drinking water. Treatment with DFMO significantly reduced cancer incidence and the average size and number of cancers per rat and prolonged the cancer-free time. DFMO appears to be effective in blocking some aspect of the promotion stage of chemically induced mammary carcinogenesis in the rat.

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Year:  1984        PMID： 6437694     DOI： 10.1093/carcin/5.12.1649

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  4 in total

Review 1.  Mammary tumorigenesis and chemoprevention studies in carcinogen-treated rats.

Authors:  C Ip
Journal:  J Mammary Gland Biol Neoplasia       Date:  1996-01       Impact factor: 2.673

2.  Hormonal control of polyamine pools in experimental breast cancer in vivo: correlation with estrogen and progesterone receptor levels.

Authors:  A Manni; B Badger; J Lynch; P Glikman; L Demers
Journal:  Breast Cancer Res Treat       Date:  1989-11       Impact factor: 4.872

3.  Role of polyamines in the growth of hormone-responsive experimental breast cancer in vivo.

Authors:  A Manni; B Badger; G Luk; C Wright; R Caplan; H Rockette; M Bartholomew; S R Ahmed
Journal:  Breast Cancer Res Treat       Date:  1988-07       Impact factor: 4.872

4.  Mechanisms of asbestos-induced squamous metaplasia in tracheobronchial epithelial cells.

Authors:  G Cameron; C D Woodworth; S Edmondson; B T Mossman
Journal:  Environ Health Perspect       Date:  1989-03       Impact factor: 9.031
  4 in total

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