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Literature DB >> 6437377

Sites of reaction of glutaraldehyde and acetaldehyde with nucleosides.

Abstract

Glutaraldehyde, a dialdehyde, was reacted with ribonucleosides and deoxyribonucleosides and the products were purified by high-performance liquid chromatography (HPLC). Multiple reaction products were identified with cytosine- and purine-containing nucleosides. The products were labile, but spectroscopic evidence indicated that exocyclic amino groups were involved. Similar reactions were seen with acetaldehyde and butyraldehyde, monofunctional aldehydes. After reduction, one of the acetaldehyde-guanosine adducts was assigned the structure N2-ethylguanosine.

Entities: Chemical

Mesh：

Substances：

Year: 1984 PMID： 6437377 DOI： 10.1007/bf00316126

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

16 in total

1. Fluorescent modification of guanine. Reaction with substituted malondialdehydes.

Authors: R C Moschel; N J Leonard
Journal: J Org Chem Date: 1976-01-23 Impact factor: 4.354

2. 1,N2-ethenoguanine and N2,3-ethenoguanine. Synthesis and comparison of the electronic spectral properties of these linear and angular triheterocycles related to the Y bases.

Authors: P D Sattsangi; N J Leonard; C R Frihart
Journal: J Org Chem Date: 1977-09-30 Impact factor: 4.354

Review 3. Reactions of nucleic acids and nucleoproteins with formaldehyde.

Authors: M Y Feldman
Journal: Prog Nucleic Acid Res Mol Biol Date: 1973

4. Reaction of nitrous acid with alkylaminopurines.

Authors: R Shapiro; S J Shiuey
Journal: Biochim Biophys Acta Date: 1969-01-21

5. Identification of guanine-adducts of carcinogens by their fluorescence.

Authors: K Hemminki
Journal: Carcinogenesis Date: 1980-04 Impact factor: 4.944

6. The reaction of guanine derivatives with 1,2-dicarbonyl compounds.

Authors: R Shapiro; J Hachmann
Journal: Biochemistry Date: 1966-09 Impact factor: 3.162

7. Isolation and identification of cross-links from formaldehyde-treated nucleic acids.

Authors: Y F Chaw; L E Crane; P Lange; R Shapiro
Journal: Biochemistry Date: 1980-11-25 Impact factor: 3.162

8. On the reaction of guanine with glyoxal, pyruvaldehyde, and kethoxal, and the structure of the acylguanines. A new synthesis of N2-alkylguanines.

Authors: R Shapiro; B I Cohen; S J Shiuey; H Maurer
Journal: Biochemistry Date: 1969-01 Impact factor: 3.162

Sites of reaction of glutaraldehyde and acetaldehyde with nucleosides.

1. Fluorescent modification of guanine. Reaction with substituted malondialdehydes.

2. 1,N2-ethenoguanine and N2,3-ethenoguanine. Synthesis and comparison of the electronic spectral properties of these linear and angular triheterocycles related to the Y bases.

Review 3. Reactions of nucleic acids and nucleoproteins with formaldehyde.

4. Reaction of nitrous acid with alkylaminopurines.

5. Identification of guanine-adducts of carcinogens by their fluorescence.

6. The reaction of guanine derivatives with 1,2-dicarbonyl compounds.

7. Isolation and identification of cross-links from formaldehyde-treated nucleic acids.

8. On the reaction of guanine with glyoxal, pyruvaldehyde, and kethoxal, and the structure of the acylguanines. A new synthesis of N2-alkylguanines.

9. Chloroacetaldehyde-treated ribo- and deoxyribopolynucleotides. 1. Reaction products.

10. Reactions of formaldehyde with guanosine.

1. Glutaraldehyde exposure and its occupational impact in the health care environment.

2. Aldehyde Production as a Calibrant of Ultrasonic Power Delivery During Protein Misfolding Cyclic Amplification.

Review 3. Interplay between Cellular Metabolism and the DNA Damage Response in Cancer.