Literature DB >> 6437007

Modulation of rapid plasminogen activator inhibitor in plasma by stanozolol.

J H Verheijen, D C Rijken, G T Chang, F E Preston, C Kluft.   

Abstract

Fibrinolytic activity in plasma euglobulin fractions can be increased by oral administration of stanozolol. This increase is not caused by increased synthesis or release of tissue-type plasminogen activator. A decreased level of fast acting t-PA inhibition is very probably the cause of the higher activity. These results suggest that this inhibition has a regulatory role on fibrinolysis in vivo.

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Year:  1984        PMID: 6437007

Source DB:  PubMed          Journal:  Thromb Haemost        ISSN: 0340-6245            Impact factor:   5.249


  6 in total

1.  Secretion of plasminogen activator inhibitor by normal rat pleural leukocytes in culture.

Authors:  X Y Li; G M Brown; D Lamb; K Donaldson
Journal:  Lung       Date:  1990       Impact factor: 2.584

2.  A controlled study of stanozolol in primary Raynaud's phenomenon and systemic sclerosis.

Authors:  M I Jayson; C D Holland; A Keegan; K Illingworth; L Taylor
Journal:  Ann Rheum Dis       Date:  1991-01       Impact factor: 19.103

3.  Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cells.

Authors:  T D Gelehrter; R Sznycer-Laszuk
Journal:  J Clin Invest       Date:  1986-01       Impact factor: 14.808

4.  Two different mechanisms in patients with venous thrombosis and defective fibrinolysis: low concentration of plasminogen activator or increased concentration of plasminogen activator inhibitor.

Authors:  I M Nilsson; H Ljungnér; L Tengborn
Journal:  Br Med J (Clin Res Ed)       Date:  1985-05-18

5.  Effect of oral defibrotide on tissue-plasminogen activator and tissue-plasminogen activator inhibitor balance.

Authors:  F Violi; D Ferro; M Saliola; C Quintarelli; S Basili; F Balsano
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

Review 6.  Clinical disorders of fibrinolysis: a critical review.

Authors:  R B Francis
Journal:  Blut       Date:  1989-07
  6 in total

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