[Skeletal side effects of treatment with prostaglandin E1].

The effects on the skeleton of the treatment of childhood ductus with prostaglandin E1 and E2 are described. Prolonged prostaglandin therapy leads to cortical hyperostosis of the diaphyses of long tubular bones, ribs, scapulae, and clavicles. There is also delay in ossification of the skull vault and widening of the sutures. After cessation of treatment, cortical hyperostosis in the long bones remains, whereas the widening of the skull sutures regresses completely.