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Literature DB >> 6436881

Glucose protects DBA/2J mice from audiogenic seizures: correlation with brain glycogen levels.

Abstract

The time courses of changes in liver, blood, and brain cortical glucose and glycogen levels were measured in 21-day-old DBA/2J mice after an IP injection of 10 g/kg glucose. Other mice were injected with glucose and tested for susceptibility to audiogenic seizures (AGS). Susceptibility to AGS fell from maximal levels to complete protection by 4 h, remained low through 6 h, then began to return to control levels by 8 h. Liver, blood, and brain glucose levels all rose to a peak soon after the injection, then fell linearly and returned to control levels by 6-8 h. Changes in brain glycogen levels reflected changes in AGS susceptibility.

Entities: Chemical Disease Species

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Year: 1984 PMID： 6436881 DOI： 10.1007/bf00432041

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

10 in total

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Authors: E M VICARI; A TRACY; A JONGBLOED
Journal: Proc Soc Exp Biol Med Date: 1952-05

2. Cerebral energy metabolism during experimental status epilepticus.

Authors: T E Duffy; D C Howse; F Plum
Journal: J Neurochem Date: 1975-05 Impact factor: 5.372

3. Preconvulsive changes in brain glucose metabolism following drugs inhibiting glutamate decarboxylase.

Authors: R W Horton; B S Meldrum
Journal: J Neurochem Date: 1976-04 Impact factor: 5.372

4. A comparison of methods for stopping intermediary metabolism of developing rat brain.

Authors: A L Miller; A Shamban
Journal: J Neurochem Date: 1977-06 Impact factor: 5.372

5. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat.

Authors: L Sokoloff; M Reivich; C Kennedy; M H Des Rosiers; C S Patlak; K D Pettigrew; O Sakurada; M Shinohara
Journal: J Neurochem Date: 1977-05 Impact factor: 5.372

6. A comparison of three methods of glycogen measurement in tissues.

Authors: J V Passonneau; V R Lauderdale
Journal: Anal Biochem Date: 1974-08 Impact factor: 3.365

7. The course of ketosis and the activity of key enzymes of ketogenesis and ketone-body utilization during development of the postnatal rat.

Authors: E A Lockwood; E Bailey
Journal: Biochem J Date: 1971-08 Impact factor: 3.857

8. Developmental changes in brain glucose, glycogen, phosphocreatine, and ATP levels in DBA/2J and C57BL/6J mice, and audiogenic seizures.

Authors: R A Schreiber
Journal: J Neurochem Date: 1981-09 Impact factor: 5.372

9. Sources of energy for the brain and susceptibility to audiogenic seizures.

Authors: R A Schreiber
Journal: Med Hypotheses Date: 1979-04 Impact factor: 1.538

10. Development of susceptibility to audiogenic seizures in DBA/2J and Rb mice: toward a systematic nomenclature of audiogenic seizure levels.

Authors: R A Schreiber; A Lehmann; B E Ginsburg; J L Fuller
Journal: Behav Genet Date: 1980-11 Impact factor: 2.805