Literature DB >> 6436732

Increase of valproate-induced hyperammonemia in normal subjects by carbohydrate intake.

J M Warter, C Marescaux, G Chabrier, L Rumbach, G Micheletti, B Reitzer, E Hirsch, M Imler.   

Abstract

Sodium valproate-induced hyperammonemia in normal subjects is increased by the intake of carbohydrates--rapidly or slowly absorbed sugars, given by mouth or IV injection. The hyperammonemia is maximal about 3 hours after carbohydrate administration. This relation between carbohydrate and ammonia metabolism has not been described previously.

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Year:  1984        PMID: 6436732     DOI: 10.1212/wnl.34.11.1487

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


  2 in total

1.  Valproic acid induction of coma in rats: synergism with NH4+ and pentobarbital.

Authors:  L Zieve; C Lyftogt
Journal:  Metab Brain Dis       Date:  1989-06       Impact factor: 3.584

Review 2.  Valproate-induced hyperammonemic encephalopathy.

Authors:  Alberto Verrotti; Daniela Trotta; Guido Morgese; Francesco Chiarelli
Journal:  Metab Brain Dis       Date:  2002-12       Impact factor: 3.584

  2 in total

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