Literature DB >> 6436440

Biosynthesis of 5-aminopentanoic acid and 2-piperidone from cadaverine and 1-piperideine in mouse.

P S Callery, L A Geelhaar.   

Abstract

1-Piperideine, 5-aminopentanoic acid, and its lactam, 2-piperidone, were identified as metabolites of cadaverine in 10,000 g mouse liver supernatants to which diamine oxidase had been added. Both metabolites were also found when the cadaverine metabolite 1-piperideine was incubated with the preparation which suggested that 1-piperideine is an intermediate in the formation of 5-aminopentanoic acid and 2-piperidone. Identification of the metabolites was based on gas chromatography-mass spectrometric analysis in comparison to authentic standards. Mouse brain homogenates converted 1-piperideine to 5-aminopentanoic acid. The results suggest that the metabolic fate of cadaverine may provide precursors of pharmacologically active analogues of GABA.

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Year:  1984        PMID： 6436440     DOI： 10.1111/j.1471-4159.1984.tb06088.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  8 in total

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2.  Distinctive metabolic profiles between Cystic Fibrosis mutational subclasses and lung function.

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Journal:  BMC Med       Date:  2021-07-14       Impact factor: 8.775

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Authors:  Marcela M Fernandez-Gutierrez; Sultan Imangaliyev; Andrei Prodan; Bruno G Loos; Bart J F Keijser; Michiel Kleerebezem
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  8 in total

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