The effect of different methods of ovarian stimulation for human in vitro fertilization and embryo replacement.

Many types of medication regimens have been used to produce ovarian stimulation for in vitro fertilization and embryo replacement. However, few comparative studies have been reported. In this investigation, 105 patients were given either clomiphene citrate alone, human menopausal gonadotropins alone, or a combination of these drugs; and the resulting number of oocytes collected, embryos produced, and pregnancies initiated are reported. The data demonstrate optimal follicle development and fertilization rates with combinations of drugs, rather than the use of a single agent. Further studies are needed to determine whether there is a statistically significant difference in pregnancy rates between groups.