Literature DB >> 6435702

Immunoglobulin light chains in chronic lymphocytic leukemia and related diseases.

F W Hirsch, M Wagner, K J Bross, K Guttkowski, G Dölken, G W Löhr.   

Abstract

The combination of two-dimensional mini gel electrophoresis with the 'western blot' technique proves to be a powerful tool in characterizing lymphoid cells. By testing for kappa and lambda immunoglobulin light chains we were able to differentiate between mono-, oligo-, and polyclonal B-cell diseases. The distribution of the lambda isotypes of 24 cases with chronic lymphocytic B-cell leukemia (B-CLL) tested was not random when compared to the distribution of the lambda light chains in B-lymphocytes of normal persons. This might implicate a genetic link between the lambda loci (chromosome 22) and the development of the lambda-CLL.

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Year:  1984        PMID： 6435702     DOI： 10.1007/bf00320208

Source DB:  PubMed          Journal:  Blut        ISSN： 0006-5242


  18 in total

1.  Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

Authors:  E E Max; J G Seidman; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

2.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

3.  Demonstration of cell surface antigens and their antibodies by the peroxidase-antiperoxidase method.

Authors:  K J Bross; G A Pangalis; C G Staatz; K G Blume
Journal:  Transplantation       Date:  1978-06       Impact factor: 4.939

4.  Normal equivalent cells of B cell malignancies: analysis with monoclonal antibodies.

Authors:  M Gobbi; F Caligaris-Cappio; G Janossy
Journal:  Br J Haematol       Date:  1983-07       Impact factor: 6.998

5.  Identification of tissue-specific nuclear antigens transferred to nitrocellulose from polyacrylamide gels.

Authors:  W F Glass; R C Briggs; L S Hnilica
Journal:  Science       Date:  1981-01-02       Impact factor: 47.728

6.  Characterization of lymphoid cells by two-dimensional mini gel electrophoresis of proteins.

Authors:  F W Hirsch; C Bröckl; K J Bross; G Dölken
Journal:  J Cancer Res Clin Oncol       Date:  1983       Impact factor: 4.553

7.  Chromosomal translocation involving the immunoglobulin kappa-chain and heavy-chain loci in a child with chronic lymphocytic leukemia.

Authors:  J A Sonnier; G R Buchanan; P N Howard-Peebles; J Rutledge; R G Smith
Journal:  N Engl J Med       Date:  1983-09-08       Impact factor: 91.245

8.  Electrophoretic transfer of DNA, RNA and protein onto diazobenzyloxymethyl (DBM) - paper.

Authors:  E J Stellwag; A E Dahlberg
Journal:  Nucleic Acids Res       Date:  1980-01-25       Impact factor: 16.971

9.  Immunoautoradiographic detection of proteins after electrophoretic transfer from gels to diazo-paper: analysis of adenovirus encoded proteins.

Authors:  J Symington; M Green; K Brackmann
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

10.  Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes.

Authors:  O W McBride; P A Hieter; G F Hollis; D Swan; M C Otey; P Leder
Journal:  J Exp Med       Date:  1982-05-01       Impact factor: 14.307
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  1 in total

1.  Serum antibodies to a normal cellular protein (P-65) in patients with Hodgkin's disease.

Authors:  F W Hirsch; J Scholl; G Dölken
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553
  1 in total

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