| Literature DB >> 6434894 |
R A Altschuld, C M Hohl, K G Lamka, G P Brierley.
Abstract
Amiloride at high concentrations inhibits the uptake of Ca by rat heart myocytes containing elevated levels of intracellular Na and retards the development of Ca-dependent hypercontracture in these cells. In contrast, amiloride enhances the net uptake of Ca in Ca-tolerant myocytes containing normal levels of Na. The results suggest that amiloride may inhibit Na-Ca exchange across the sarcolemma of cardiac myocytes.Entities:
Mesh：
Substances：
Year: 1984 PMID： 6434894 DOI： 10.1016/0024-3205(84)90412-0
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037