Literature DB >> 6434345

A phorbol ester and A23187 act synergistically to release acetylcholine from the guinea pig ileum.

C Tanaka, K Taniyama, M Kusunoki.   

Abstract

Electrical stimulation of guinea pig ileum preloaded with [3H]choline provokes the release of [3H]acetylcholine (ACh) in a Ca2+-dependent manner. This release was markedly increased by the tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA). The combination of the ionophore A23187 and TPA produced the release of [3H]ACh up to a level equal to or exceeding a maximal response induced by electrical stimulation. A23187 alone gave only a minor response and TPA alone had no apparent effect on the [3H]ACh release. Thus, protein kinase C probably plays a role in cell surface signal transduction related to the release of transmitters from nerve endings.

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Year:  1984        PMID： 6434345     DOI： 10.1016/0014-5793(84)80591-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.

Authors:  I N Maruyama; S Brenner
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

Review 2.  The role of protein kinase C and its neuronal substrates dephosphin, B-50, and MARCKS in neurotransmitter release.

Authors:  P J Robinson
Journal:  Mol Neurobiol       Date:  1991       Impact factor: 5.590

3.  The structural requirements for phorbol esters to enhance serotonin and acetylcholine release from rat brain cortex.

Authors:  L Iannazzo; P Kotsonis; H Majewski
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

Review 4.  The role of phosphoinositides in signal transduction.

Authors:  M C Sekar; L E Hokin
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

5.  Protein kinase c-beta-like immunoreactivity in the developing and adult rat adrenal gland.

Authors:  R Roivainen; M Pelto-Huikko; M Hietanen-Peltola; J Koistinaho
Journal:  Histochem J       Date:  1991-08

Review 6.  Mechanisms in the regulation of neurotransmitter release from brain nerve terminals: current hypotheses.

Authors:  T S Sihra; R A Nichols
Journal:  Neurochem Res       Date:  1993-01       Impact factor: 3.996

7.  Sensitizing stimuli cause translocation of protein kinase C in Aplysia sensory neurons.

Authors:  T C Sacktor; J H Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

8.  Phorbol ester, an activator of protein kinase C, enhances calcium-dependent release of sympathetic neurotransmitter.

Authors:  A R Wakade; R K Malhotra; T D Wakade
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-10       Impact factor: 3.000

9.  Phorbol myristate acetate ex vivo model of enhanced colonic epithelial permeability. Reactive oxygen metabolite and protease independence.

Authors:  M C Berin; M G Buell
Journal:  Dig Dis Sci       Date:  1995-10       Impact factor: 3.199

10.  The phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate, enhances the evoked quanta release of acetylcholine at the frog neuromuscular junction.

Authors:  C Haimann; J Meldolesi; B Ceccarelli
Journal:  Pflugers Arch       Date:  1987-01       Impact factor: 3.657
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