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Literature DB >> 6434013

Differential effect of cyclo-oxygenase inhibition on antigen- and ionophore-induced release of slow reacting substance from fragmented guinea-pig lung.

Abstract

The nonsteroidal anti-inflammatory drugs (NSAID) indomethacin and mefenamic acid, at concentrations ranging from 3 microM to 18 microM, enhanced antigen-induced slow reacting substance of anaphylaxis (SRS-A) release from sensitized fragmented guinea-pig lung. In contrast, these agents had no effect on SRS-A release from nonsensitized guinea-pig lung induced by several concentrations of the calcium ionophore, A23187. Neither increasing preincubation time with the NSAID nor the use of sensitized tissue resulted in an enhancement of A23187-induced SRS-A release by indomethacin. NSAID did not alter histamine release by either stimulus. These results suggest that antigen and A23187 induce SRS-A release from different sources or by different mechanisms in guinea-pig lung.

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Year: 1984 PMID： 6434013 PMCID： PMC1986932 DOI： 10.1111/j.1476-5381.1984.tb16484.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

22 in total

1. Release of slow-reacting substance from guinea-pig and human lung by calcium ionophore A23187 [proceedings].

Authors: P J Piper; J P Seale
Journal: Br J Pharmacol Date: 1978-06 Impact factor: 8.739

2. Release of mediators from free bronchoalveolar cells: effect of ionophore A23187 and antigen challenge.

Authors: P Sirois
Journal: J Immunopharmacol Date: 1980

3. Role of arachidonic acid in the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) from sensitized guinea pig lung fragments: evidence that SRS-A is very similar or identical structurally to nonimmunologically induced forms of SRS.

Authors: S Watanabe-Kohno; C W Parker
Journal: J Immunol Date: 1980-08 Impact factor: 5.422

4. Indomethacin increases the production of SRS-A by the ileum from sensitized guinea-pigs.

Authors: G M Laekeman; A G Herman
Journal: Arch Int Pharmacodyn Ther Date: 1979-12

5. Evidence for lipoxygenase pathway involvement in allergic tracheal contraction.

Authors: J F Burka; N A Paterson
Journal: Prostaglandins Date: 1980-04

6. The influence of a new corticosteroid, budesonide, on anaphylactic bronchoconstriction and SRS-A release in the guinea pig.

Authors: K Forsberg; L Sörenby
Journal: Agents Actions Date: 1981-07

7. Effects of modulators of arachidonic acid metabolism on the synthesis and release of slow-reacting substance of anaphylaxis.

Authors: J F Burka; R J Flower
Journal: Br J Pharmacol Date: 1979-01 Impact factor: 8.739

8. Evidence for two sources of arachidonic acid for oxidative metabolism by mouse peritoneal macrophages.

Authors: J L Humes; S Sadowski; M Galavage; M Goldenberg; E Subers; R J Bonney; F A Kuehl
Journal: J Biol Chem Date: 1982-02-25 Impact factor: 5.157

9. Effect of inhibitors of prostaglandin synthesis and prostaglandins E2 and F2alpha on the immunologic release of mediators of inflammation from actively sensitized guinea-pig lung.

Authors: M Hitchcock
Journal: J Pharmacol Exp Ther Date: 1978-11 Impact factor: 4.030

10. Release of mediators of anaphylaxis: inhibition of prostaglandin synthesis and the modification of release of slow reacting substance of anaphylaxis and histamine.

Authors: D M Engineer; U Niederhauser; P J Piper; P Sirois
Journal: Br J Pharmacol Date: 1978-01 Impact factor: 8.739

3 in total