| Literature DB >> 6433549 |
G Terenghi, J M Polak, J Ballesta, D Cocchia, F Michetti, D Dahl, P J Marangos, A Garner.
Abstract
An immunocytochemical study of 30 retinoblastomas was carried out using antibodies to neuronal and glial markers. The tumours were found to react with antibodies to neuron-specific enolase (NSE), a marker for neuronal elements, and S-100 and glial fibrillary acidic protein (GFAP), both of which are proteins present in glia. Two distinct cell populations were found within the tumour: the first, composed of anaplastic tumour cells at various stages of differentiation, showed both NSE and S-100 immunoreactivity; the second cell type, which immuno-stained for S-100 and GFAP, resembled mature glial cells. The results of this study indicate that the retinoblastoma may arise from a pluripotential primitive cell partially retaining neuronal and glial characteristics.Entities:
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Year: 1984 PMID： 6433549 DOI： 10.1007/bf00704251
Source DB: PubMed Journal: Virchows Arch A Pathol Anat Histopathol ISSN： 0174-7398