Literature DB >> 6432763

A new antitumor antibiotic, kazusamycin.

I Umezawa, K Komiyama, H Oka, K Okada, S Tomisaka, T Miyano, S Takano.   

Abstract

A new antibiotic kazusamycin, was isolated from the culture broth of Streptomyces sp. No. 81-484, which shows antitumor activity against experimental murine tumors. This antibiotic did not possess antibacterial activity against Gram-positive and Gram-negative bacteria, but showed strong cytotoxic activity against HeLa cells in vitro. The chemical and physico-chemical properties of kazusamycin suggest that the molecular formula of this antibiotic is C33H48O7 (MW 556).

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Year:  1984        PMID： 6432763     DOI： 10.7164/antibiotics.37.706

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  4 in total

Review 1.  Thom Award Lecture. Trends in the search for bioactive microbial metabolites.

Authors:  S Omura
Journal:  J Ind Microbiol       Date:  1992-09

2.  Applications of thin layer chromatography, high performance liquid chromatography and mass spectrometry in the fermentation and isolation of the antibiotic nybomycin.

Authors:  J A Pope; R A Nelson; C P Schaffner; R T Rosen; R C Pandey
Journal:  J Ind Microbiol       Date:  1990-09

3.  Bioactive compounds from marine actinomycetes.

Authors:  Renu Solanki; Monisha Khanna; Rup Lal
Journal:  Indian J Microbiol       Date:  2009-01-08       Impact factor: 2.461

4.  In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI-940 and its hydroxy analog (PD 114,721).

Authors:  B J Roberts; K L Hamelehle; J S Sebolt; W R Leopold
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333
  4 in total

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