Literature DB >> 6432580

Hydrocortisone inhibits prostaglandin production but not arachidonic acid release from cultured macrophages.

J N Wood, P R Coote, J Rhodes.   

Abstract

We have investigated the action of hydrocortisosone on arachidonic acid mobilisation in cultures of mouse peritoneal macrophages, mouse L929 cells and the mouse macrophage-like cell line RAW264. Hydrocortisone inhibits both arachidonic acid release and prostaglandin production by L929 cells. However, prostaglandin production by macrophages or RAW264 cells is inhibited with a concomitant stimulation rather than inhibition of arachidonic acid release. These data suggest that hydrocortisone acts at the level of phospholipase activity in fibroblasts but at a later stage of prostanoid production in macrophages.

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Year:  1984        PMID： 6432580     DOI： 10.1016/0014-5793(84)81093-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  3 in total

1.  Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice.

Authors:  J L Masferrer; B S Zweifel; K Seibert; P Needleman
Journal:  J Clin Invest       Date:  1990-10       Impact factor: 14.808

2.  Glucocorticoids inhibit prostaglandin synthesis not only at the level of phospholipase A2 but also at the level of cyclo-oxygenase/PGE isomerase.

Authors:  M Goppelt-Struebe; D Wolter; K Resch
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

3.  Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases.

Authors:  A Raz; A Wyche; P Needleman
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205
  3 in total

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