Literature DB >> 6432555

A Mott cell hybridoma.

S Weiss, P D Burrows, J Meyer, M R Wabl.   

Abstract

A hybridoma is described that exhibits all the characteristic features of Mott cells. It has spherules (Russell bodies) in the cytoplasm made up of dilated rough endoplasmatic reticulum and containing condensed immunoglobulin (lambda 1 light chains). Some of the cells appear to be very fragile, and free spherules are often found on cell smears. Cells with the Mott cell characteristics are still able to divide, but they do not secrete immunoglobulin. Hybridomas of this kind should be useful for determining the place of the Mott cell within the scheme of B cell differentiation.

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Year:  1984        PMID： 6432555     DOI： 10.1002/eji.1830140814

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  8 in total

1.  A different sort of Mott cell.

Authors:  H M Jäck; G Beck-Engeser; B Sloan; M L Wong; M Wabl
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205

2.  The formation, function and fate of protein storage compartments in seeds.

Authors:  Verena Ibl; Eva Stoger
Journal:  Protoplasma       Date:  2011-05-26       Impact factor: 3.356

3.  Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic.

Authors:  Haruki Hasegawa; Ann Hsu; Christine E Tinberg; Karen E Siegler; Aaron A Nazarian; Mei-Mei Tsai
Journal:  MAbs       Date:  2017-04-05       Impact factor: 5.857

4.  Development of plasmacytoid cells with Russell bodies in autoimmune "viable motheaten" mice.

Authors:  L D Shultz; D R Coman; B L Lyons; C L Sidman; S Taylor
Journal:  Am J Pathol       Date:  1987-04       Impact factor: 4.307

5.  Aggregates, crystals, gels, and amyloids: intracellular and extracellular phenotypes at the crossroads of immunoglobulin physicochemical property and cell physiology.

Authors:  Haruki Hasegawa
Journal:  Int J Cell Biol       Date:  2013-03-05

6.  Synthesis of abnormal immunoglobulins by hybridomas from autoimmune "viable motheaten" mutant mice.

Authors:  P A Schweitzer; S E Taylor; L D Shultz
Journal:  J Cell Biol       Date:  1991-07       Impact factor: 10.539

7.  Russell-Like Bodies in Plant Seeds Share Common Features With Prolamin Bodies and Occur Upon Recombinant Protein Production.

Authors:  Elsa Arcalis; Verena Ibl; Julia Hilscher; Thomas Rademacher; Linda Avesani; Francesca Morandini; Luisa Bortesi; Mario Pezzotti; Alessandro Vitale; Dietmar Pum; Thomas De Meyer; Ann Depicker; Eva Stoger
Journal:  Front Plant Sci       Date:  2019-06-26       Impact factor: 5.753

8.  Russell bodies: a general response of secretory cells to synthesis of a mutant immunoglobulin which can neither exit from, nor be degraded in, the endoplasmic reticulum.

Authors:  C Valetti; C E Grossi; C Milstein; R Sitia
Journal:  J Cell Biol       Date:  1991-11       Impact factor: 10.539
  8 in total

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