Literature DB >> 6432499

Omeprazole inhibits nocturnal and pentagastrin-stimulated gastric secretion in man.

J A Wilson, E J Boyd, K G Wormsley.   

Abstract

The effect of omeprazole on the overnight and pentagastrin-stimulated gastric secretion of acid and pepsin have been studied in healthy male volunteers. After treatment with omeprazole, 30 mg or 60 mg daily for one week, overnight secretion of acid was reduced by 48 and 73%, respectively. During stimulation with pentagastrin, a single dose of 40 mg omeprazole reduced acid output by 98%, while after 80 mg, secretion of acid and pepsin was completely abolished. Omeprazole is one of the most potent gastric secretory inhibitors available at present, with potential for use in the therapy of ulcer disease.

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Year:  1984        PMID： 6432499     DOI： 10.1007/bf01318421

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  7 in total

1.  A modified hemoglobin substrate method for the estimation of pepsin in gastric juice.

Authors:  A Berstad
Journal:  Scand J Gastroenterol       Date:  1970       Impact factor: 2.423

2.  Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase.

Authors:  E Fellenius; T Berglindh; G Sachs; L Olbe; B Elander; S E Sjöstrand; B Wallmark
Journal:  Nature       Date:  1981-03-12       Impact factor: 49.962

3.  Rapid healing of duodenal ulcers with omeprazole: double-blind dose-comparative trial.

Authors:  S Gustavsson; H O Adami; L Lööf; A Nyberg; O Nyrén
Journal:  Lancet       Date:  1983-07-16       Impact factor: 79.321

4.  Inhibition of pentagastrin-stimulated and nocturnal gastric secretion by ranitidine. A new H2-receptor antagonist.

Authors:  N R Peden; J H Saunders; K G Wormsley
Journal:  Lancet       Date:  1979-03-31       Impact factor: 79.321

5.  Effect of omeprazole--a gastric proton pump inhibitor--on pentagastrin stimulated acid secretion in man.

Authors:  T Lind; C Cederberg; G Ekenved; U Haglund; L Olbe
Journal:  Gut       Date:  1983-04       Impact factor: 23.059

6.  [Behavior of acid secretion under the long-term daily administration of omeprazol].

Authors:  H G Dammann; P Müller; H K Seitz; B Simon
Journal:  Schweiz Med Wochenschr       Date:  1983-06-18

7.  Effect of daily oral omeprazole on 24 hour intragastric acidity.

Authors:  R P Walt; M D Gomes; E C Wood; L H Logan; R E Pounder
Journal:  Br Med J (Clin Res Ed)       Date:  1983-07-02
  7 in total
  7 in total

1.  Effect of single and repeated intravenous doses of omeprazole on pentagastrin stimulated gastric acid secretion and pharmacokinetics in man.

Authors:  J B Jansen; P Lundborg; L C Baak; J Greve; M Ohman; C Stöver; K Röhss; C B Lamers
Journal:  Gut       Date:  1988-01       Impact factor: 23.059

2.  Inhibition of human gastric secretion by ICI 162,846--a new histamine H2-receptor antagonist.

Authors:  J A Wilson; D A Johnston; J Penston; K G Wormsley
Journal:  Br J Clin Pharmacol       Date:  1986-06       Impact factor: 4.335

Review 3.  Omeprazole. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peptic ulcer disease and Zollinger-Ellison syndrome.

Authors:  S P Clissold; D M Campoli-Richards
Journal:  Drugs       Date:  1986-07       Impact factor: 9.546

4.  Effect of lansoprazole on intragastric pH. Comparison between morning and evening dosing.

Authors:  M Hongo; S Ohara; Y Hirasawa; S Abe; S Asaki; T Toyota
Journal:  Dig Dis Sci       Date:  1992-06       Impact factor: 3.199

5.  Comparison of the effects of gastric antisecretory agents in healthy volunteers and patients with duodenal ulcer.

Authors:  C W Howden; D B Jones; D W Burget; R H Hunt
Journal:  Gut       Date:  1986-09       Impact factor: 23.059

6.  Effectiveness of omeprazole in seven patients with Zollinger-Ellison syndrome resistant to histamine H2-receptor antagonists.

Authors:  J C Delchier; J C Soule; M Mignon; D Goldfain; A Cortot; B Travers; J P Isal; J P Bader
Journal:  Dig Dis Sci       Date:  1986-07       Impact factor: 3.199

7.  Bioavailability and efficacy of omeprazole given orally and by nasogastric tube.

Authors:  C Larson; N J Cavuto; D A Flockhart; R B Weinberg
Journal:  Dig Dis Sci       Date:  1996-03       Impact factor: 3.199
  7 in total

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