Literature DB >> 6431452

Formation of 6-hydroxydopamine in caudate nucleus of the rat brain after a single large dose of methylamphetamine.

L S Seiden, G Vosmer.   

Abstract

We now report that 6-hydroxydopamine (0.39 +/- 0.31 nanograms/mg of tissue at 2 hr) is formed in the rat caudate nucleus after a single injection of methylamphetamine (100 mg/kg). The same dose of methylamphetamine causes approximately 50% depletion of caudate dopamine 2 weeks after the injection. We suggest that the formation of 6-hydroxydopamine from endogenous dopamine is responsible for the neurotoxicity to dopamine terminals seen after methylamphetamine administration.

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Year:  1984        PMID： 6431452     DOI： 10.1016/0091-3057(84)90125-4

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  23 in total

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