| Literature DB >> 6431413 |
M Akmal, S Tuma, D A Goldstein, R Pattabhiraman, L Bernstein, S G Massry.
Abstract
In order to examine whether parathyroid hormone (PTH) enters the cerebrospinal fluid (CSF), the blood levels of the hormone were acutely elevated either by infusion of parathyroid extract or by stimulation of the parathyroid glands by hypocalcemia. Despite marked elevations in the blood levels of the hormone, PTH could not be detected in the CSF. The data indicate the intact PTH or its carboxyterminal fragment do not cross the blood-CSF interface of the blood-brain barrier. The results, therefore, suggest that the action of PTH on brain must be mediated by an effect on the blood-brain interface of the blood-brain barrier.Entities:
Mesh：
Substances：
Year: 1984 PMID： 6431413 DOI： 10.3181/00379727-176-41894
Source DB: PubMed Journal: Proc Soc Exp Biol Med ISSN： 0037-9727