Literature DB >> 6431181

An evaluation of tribromoethanol (TBE) as an anaesthetic agent in the Mongolian gerbil (Meriones unguiculatus).

M L Norris, W D Turner.   

Abstract

Mongolian gerbils injected i.p. with a 1.25% solution of tribromoethanol (TBE) quickly lost the righting reflex and showed good surgical anaesthesia, the duration of which was positively related to the dose administered. All levels (225-450 mg/kg bodyweight) of TBE injected s.c. resulted in loss of the righting reflex, though surgical anaesthesia was not attained. Following recovery from anaesthesia induced with 2.25% TBE i.p., or high doses of 1.25% TBE i.p., visceral adhesions and deaths occurred. To avoid these TBE-induced fatalities such extreme care must be taken during the preparation, storage and administration of the agent that it is not recommended as a suitable anaesthetic for general use in the gerbil.

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Year:  1983        PMID: 6431181     DOI: 10.1258/002367783781062370

Source DB:  PubMed          Journal:  Lab Anim        ISSN: 0023-6772            Impact factor:   2.471


  4 in total

1.  Increased anesthesia time using 2,2,2-tribromoethanol-chloral hydrate with low impact on mouse psychoacoustics.

Authors:  Kathleen J Maheras; Alexander Gow
Journal:  J Neurosci Methods       Date:  2013-07-12       Impact factor: 2.390

2.  Refinements for embryo implantation surgery in the mouse: comparison of injectable and inhalant anesthesias - tribromoethanol, ketamine and isoflurane - on pregnancy and pup survival.

Authors:  William B Norton; Ferdinando Scavizzi; Chad N Smith; Wenli Dong; Marcello Raspa; Jan V Parker-Thornburg
Journal:  Lab Anim       Date:  2015-11-12       Impact factor: 2.471

3.  Repeated administration of tribromoethanol in C57BL/6NHsd mice.

Authors:  William A Hill; Jacquelyn T Tubbs; Christopher L Carter; Jane A Czarra; Kimberly M Newkirk; Tim E Sparer; Barton Rohrbach; Christine M Egger
Journal:  J Am Assoc Lab Anim Sci       Date:  2013-03       Impact factor: 1.232

4.  A cyclodextrin formulation to improve use of the anesthetic tribromoethanol (Avertin(®)).

Authors:  Arlene McDowell; Jessica A Fothergill; Azeem Khan; Natalie J Medlicott
Journal:  J Pharm Bioallied Sci       Date:  2014-01
  4 in total

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