Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A two-stage mouse skin carcinogenesis study of lyngbyatoxin A.

Literature DB >> 6430909

A two-stage mouse skin carcinogenesis study of lyngbyatoxin A.

H Fujiki, M Suganuma, H Hakii, G Bartolini, R E Moore, S Takayama, T Sugimura.

Abstract

A strong skin irritant, lyngbyatoxin A, isolated from the marine blue-green alga Lyngbya majuscula is structurally related to teleocidin. Since lyngbyatoxin A satisfied our short-term screening tests for possible tumor promoters, viz. irritation of mouse ear, induction of ornithine decarboxylase (ODC) in mouse skin, and adhesion of human promyelocytic leukemia cells (HL-60), a two-stage carcinogenesis experiment was carried out. Tumor incidences in the groups treated with 7,12-dimethylbenz(a)anthracene (DMBA) plus lyngbyatoxin A and with DMBA plus 12-O-tetradecanoylphorbol-13-acetate (TPA) were 86.7% and 93.3% in week 30, respectively. The average number of tumors per mouse was 3.7 in the former group and 10.5 in the latter group. This paper reports for the first time the potent tumor-promoting activity of lyngbyatoxin A and also the histological examination of tumors.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1984 PMID： 6430909 DOI： 10.1007/bf00390993

Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN： 0171-5216 Impact factor: 4.553

13 in total

1. Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin.

Authors: H Fujiki; Y Tanaka; R Miyake; U Kikkawa; Y Nishizuka; T Sugimura
Journal: Biochem Biophys Res Commun Date: 1984-04-30 Impact factor: 3.575

2. Teleocidin: new naturally occurring tumor promoter.

Authors: T Sugimura; H Fujiki; M Mori; M Nakayasu; M Terada; K Umezawa; R E Moore
Journal: Carcinog Compr Surv Date: 1982

Review 3. Potent tumor promoters other than phorbol ester and their significance.

Authors: T Sugimura
Journal: Gan Date: 1982-08

4. Stimulation of prostaglandin production and choline turnover in HeLa cells by lyngbyatoxin A and dihydroteleocidin B.

Authors: H Sakamoto; M Terada; H Fujiki; M Mori; M Nakayasu; T Sugimura; I B Weinstein
Journal: Biochem Biophys Res Commun Date: 1981-09-16 Impact factor: 3.575

5. Seaweed dermatitis: structure of lyngbyatoxin A.

Authors: J H Cardellina; F J Marner; R E Moore
Journal: Science Date: 1979-04-13 Impact factor: 47.728

6. Activation of the EBV-cycle and aggregation of human blood lymphocytes by the tumor promoters teleocidin, lyngbyatoxin A, aplysiatoxin and debromoaplysiatoxin.

Authors: L Eliasson; B Kallin; M Patarroyo; G Klein; H Fujiki; T Sugimura
Journal: Int J Cancer Date: 1983-01-15 Impact factor: 7.396

7. Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters.

Authors: H Fujiki; M Mori; M Nakayasu; M Terada; T Sugimura; R E Moore
Journal: Proc Natl Acad Sci U S A Date: 1981-06 Impact factor: 11.205

8. Teleocidin from Streptomyces is a potent promoter of mouse skin carcinogenesis.

Authors: H Fujiki; M Suganuma; N Matsukura; T Sugimura; S Takayama
Journal: Carcinogenesis Date: 1982 Impact factor: 4.944

9. Enhanced incorporation of radioactive inorganic phosphate into phospholipids of HeLa cells by tumor promoters.

Authors: H Nishino; H Fujiki; M Terada; S Sato
Journal: Carcinogenesis Date: 1983 Impact factor: 4.944

10. New classes of environmental tumor promoters: indole alkaloids and polyacetates.

Authors: H Fujiki; T Sugimura; R E Moore
Journal: Environ Health Perspect Date: 1983-04 Impact factor: 9.031

6 in total

1. Effect of biological toxins on gap-junctional intercellular communication in Chinese hamster V79 cells.

Authors: C Jone; L Erickson; J E Trosko; C C Chang
Journal: Cell Biol Toxicol Date: 1987-03 Impact factor: 6.691

Review 2. Cyclic peptides and depsipeptides from cyanobacteria: a review.

Authors: R E Moore
Journal: J Ind Microbiol Date: 1996-02

Review 3. Structural insights into C1-ligand interactions: Filling the gaps by in silico methods.

Authors: Sachin Katti; Tatyana I Igumenova
Journal: Adv Biol Regul Date: 2021-01-18

Review 4. Is protein phosphatase inhibition responsible for the toxic effects of okadaic Acid in animals?

Authors: Rex Munday
Journal: Toxins (Basel) Date: 2013-02-04 Impact factor: 4.546

Review 5. Bloom Dynamics of Cyanobacteria and Their Toxins: Environmental Health Impacts and Mitigation Strategies.

Authors: Rajesh P Rastogi; Datta Madamwar; Aran Incharoensakdi
Journal: Front Microbiol Date: 2015-11-17 Impact factor: 5.640

Review 6. Cyanobacterial Toxins of the Laurentian Great Lakes, Their Toxicological Effects, and Numerical Limits in Drinking Water.

Authors: Todd R Miller; Lucas J Beversdorf; Chelsea A Weirich; Sarah L Bartlett
Journal: Mar Drugs Date: 2017-06-02 Impact factor: 5.118

6 in total