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Literature DB >> 643069

Why do nucleic acids have 3'5' phosphodiester bonds?

Abstract

Details of the stereochemistry of the 2'5' and 3'5' dinucleoside monophosphates of polynucleotides have been delineated in aqueous solution using nuclear magnetic resonance spectroscopy. Incorporation of these experimentally determined geometries into the structure of polynucleotides reveals that the intrinsic spatial configurations of the 2'5' bonds cannot support helical structures whereas the geometries of 3'5' bonds allow the formation of helical configurations for RNA.

Entities: Chemical

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Year: 1978 PMID： 643069 DOI： 10.1038/272798a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

10 in total

1. Visualisation of a 2'-5' parallel stranded double helix at atomic resolution: crystal structure of cytidylyl-2',5'-adenosine.

Authors: R Kirshnan; T P Seshadri; M A Viswamitra
Journal: Nucleic Acids Res Date: 1991-01-25 Impact factor: 16.971

2. Association of 2'-5' oligoribonucleotides.

Authors: R Kierzek; L He; D H Turner
Journal: Nucleic Acids Res Date: 1992-04-11 Impact factor: 16.971

3. Conformational studies of (2'-5') polynucleotides: theoretical computations of energy, base morphology, helical structure, and duplex formation.

Authors: A R Srinivasan; W K Olson
Journal: Nucleic Acids Res Date: 1986-07-11 Impact factor: 16.971

4. Structural insights into the effects of 2'-5' linkages on the RNA duplex.

Authors: Jia Sheng; Li Li; Aaron E Engelhart; Jianhua Gan; Jiawei Wang; Jack W Szostak
Journal: Proc Natl Acad Sci U S A Date: 2014-02-10 Impact factor: 11.205

5. Comparative spectroscopic, calorimetric, and computational studies of nucleic acid complexes with 2',5"-versus 3',5"-phosphodiester linkages.

Authors: R Jin; W H Chapman; A R Srinivasan; W K Olson; R Breslow; K J Breslauer
Journal: Proc Natl Acad Sci U S A Date: 1993-11-15 Impact factor: 11.205

6. X-ray structure of a dinucleoside monophosphate A2'p5'C that contains a 2'-5' link found in (2'-5')oligo(A)s induced by interferons: single-stranded helical conformation of 2'-5'-linked oligonucleotides.

Authors: R Parthasarathy; M Malik; S M Fridey
Journal: Proc Natl Acad Sci U S A Date: 1982-12 Impact factor: 11.205

Why do nucleic acids have 3'5' phosphodiester bonds?

1. Visualisation of a 2'-5' parallel stranded double helix at atomic resolution: crystal structure of cytidylyl-2',5'-adenosine.

2. Association of 2'-5' oligoribonucleotides.

3. Conformational studies of (2'-5') polynucleotides: theoretical computations of energy, base morphology, helical structure, and duplex formation.

4. Structural insights into the effects of 2'-5' linkages on the RNA duplex.

5. Comparative spectroscopic, calorimetric, and computational studies of nucleic acid complexes with 2',5"-versus 3',5"-phosphodiester linkages.

6. X-ray structure of a dinucleoside monophosphate A2'p5'C that contains a 2'-5' link found in (2'-5')oligo(A)s induced by interferons: single-stranded helical conformation of 2'-5'-linked oligonucleotides.

7. Recognition and catalysis in nucleic acid chemistry.

8. Structural insights into RNA duplexes with multiple 2΄-5΄-linkages.

9. 2'/3' Regioselectivity of Enzyme-Free Copying of RNA Detected by NMR.

Review 10. The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation.