Literature DB >> 6428699

Two dose Augmentin treatment of acute gonorrhoea in men.

K B Lim, V S Rajan, Y C Giam, E O Lui, E H Sng, K L Yeo.   

Abstract

We studied 192 men with acute gonococcal urethritis, 97 of whom received two oral doses of Augmentin (amoxycillin 3 g and clavulanic acid 250 mg) separated by a four hour interval; the remaining 95 received 2 g kanamycin in a single intramuscular injection. Of the patients treated with Augmentin, 93 (95.9%) were cured, which was significantly more than the 83 (87.4%) patients treated with kanamycin. Augmentin was equally effective in the treatment of penicillinase producing Neisseria gonorrhoeae (PPNG) and non-PPNG infections, the cure rates for which were 96.6% and 95.6% respectively.

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Year:  1984        PMID: 6428699      PMCID: PMC1046291          DOI: 10.1136/sti.60.3.161

Source DB:  PubMed          Journal:  Br J Vener Dis        ISSN: 0007-134X


  10 in total

1.  Antibiotic susceptibility of Neisseria gonorrhoeae strains from Europe and Africa.

Authors:  P Piot; E van Dyck; J Colaert; J P Ursi; E Bosmans; A Meheus
Journal:  Antimicrob Agents Chemother       Date:  1979-04       Impact factor: 5.191

2.  Epidemiology and treatment of penicillinase-producing Neisseria gonorrhoeae.

Authors:  P L Perine; R S Morton; P Piot; M S Siegel; G M Antal
Journal:  Sex Transm Dis       Date:  1979 Apr-Jun       Impact factor: 2.830

3.  Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus.

Authors:  C Reading; M Cole
Journal:  Antimicrob Agents Chemother       Date:  1977-05       Impact factor: 5.191

4.  Spectinomycin dihydrochloride treatment of gonorrhoea.

Authors:  V S Rajan; Y O Leong
Journal:  Singapore Med J       Date:  1972-06       Impact factor: 1.858

5.  Penicillinase-producing Neisseria gonorrhoeae.

Authors:  W A Ashford; R G Golash; V G Hemming
Journal:  Lancet       Date:  1976-09-25       Impact factor: 79.321

6.  Beta-lactamase-producing, penicillin-resistant gonococcus.

Authors:  I Phillips
Journal:  Lancet       Date:  1976-09-25       Impact factor: 79.321

7.  Susceptibility of Neisseria gonorrhoeae to cefotaxime and ceftizoxime.

Authors:  E H Sng; V S Rajan; R Pang; K L Yeo
Journal:  Br J Vener Dis       Date:  1981-06

8.  Simple method for detecting penicillinase-producing Neisseria gonorrhoeae and Staphylococcus aureus.

Authors:  E H Sng; K L Yeo; V S Rajan
Journal:  Br J Vener Dis       Date:  1981-04

9.  Inhibition of beta-lactamase in Neisseria gonorrhoeae by sodium clavulanate.

Authors:  J M Miller; C N Baker; C Thornsberry
Journal:  Antimicrob Agents Chemother       Date:  1978-11       Impact factor: 5.191

10.  HR 756--a new cephalosporin in the treatment of gonorrhoea caused by ordinary and penicillinase-producing strains of Neisseria gonorrhoeae.

Authors:  V S Rajan; E H Sng; R Pang; N J Tan; T Thirumoorthy; K L Yeo
Journal:  Br J Vener Dis       Date:  1980-08
  10 in total
  5 in total

1.  Chromosomally mediated intrinsic resistance to penicillin of penicillinase producing strains of Neisseria gonorrhoeae isolated in Sydney: guide to treatment with Augmentin.

Authors:  J W Tapsall; E A Phillips; L M Morris
Journal:  Genitourin Med       Date:  1987-10

2.  Incidence of gonorrhoea due to penicillinase producing Neisseria gonorrhoeae in Japan 1981-3 and treatment using a new antibiotic combination, BRL25000 (amoxycillin and clavulanic acid).

Authors:  K Osato; H Tsugami; K Harada; J Maruyama
Journal:  Genitourin Med       Date:  1986-06

3.  Three regimens of procaine penicillin G, Augmentin, and probenecid compared for treating acute gonorrhoea in men.

Authors:  K B Lim; T Thirumoorthy; C T Lee; E H Sng; T Tan
Journal:  Genitourin Med       Date:  1986-04

Review 4.  Amoxicillin/clavulanic acid. An update of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  P A Todd; P Benfield
Journal:  Drugs       Date:  1990-02       Impact factor: 9.546

5.  Single dose oral amoxycillin 3 g with either 125 mg or 250 mg clavulanic acid to treat uncomplicated anogenital gonorrhoea.

Authors:  A G Lawrence; D C Shanson
Journal:  Genitourin Med       Date:  1985-06
  5 in total

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