| Literature DB >> 6427721 |
Abstract
The oral mucosa of mice is resistant to the action of a variety of carcinogens. In this study, the water-soluble carcinogen 4-nitroquinoline-1-oxide (4NQO) was applied repeatedly to the palates of male CBA mice for 2, 4, 6, 8, 12, or 16 weeks, and the animals were observed for the remainder of the 50-week experimental period. Oral epithelial atypia and squamous cell carcinoma were observed with increasing prevalence as the period of carcinogen exposure was increased. Carcinomas developed by 50 weeks in all animals that received 4NQO for 16 weeks.Entities:
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Year: 1984 PMID： 6427721 DOI： 10.1016/0030-4220(84)90312-8
Source DB: PubMed Journal: Oral Surg Oral Med Oral Pathol ISSN： 0030-4220