Literature DB >> 6426700

Supersensitivity to the respiratory stimulatory effect of TRH in 5,7-dihydroxytryptamine-treated rats.

R A Mueller, A C Towle, G R Breese.   

Abstract

Rats treated neonatally with pargyline and 5,7-dihydroxytryptamine (5,7-DHT) have an elevated paCO2 and reduced minute ventilation when given 0.7% halothane in oxygen as adults. Serotonin content in the spinal cord of 5,7-DHT treated rats was undetectable and TRH content was reduced by 35%. The 5,7-DHT treated rats were supersensitive to the increase in minute ventilation and CO2 sensitivity produced by intraventricular TRH. It is possible that the supersensitivity to exogenous TRH after neonatal 5,7-DHT treatment may be secondary to decreased availability of TRH in the CNS.

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Year:  1984        PMID： 6426700     DOI： 10.1016/0006-8993(84)91440-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  13 in total

1.  Effects of thyroliberin on membrane potential and the pattern of spontaneous activity of neurons in the respiratory center in in vitro studies in rats.

Authors:  A N Inyushkin
Journal:  Neurosci Behav Physiol       Date:  2004-06

2.  Enhanced selective 5-HT depletions in the DHT rat model: denervation supersensitivity and recovery of function.

Authors:  M R Pranzatelli; S R Snodgrass
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

3.  Quantification of the response of rat medullary raphe neurones to independent changes in pH(o) and P(CO2).

Authors:  Wengang Wang; Stefania Risso Bradley; George B Richerson
Journal:  J Physiol       Date:  2002-05-01       Impact factor: 5.182

4.  Chemosensitivity of rat medullary raphe neurones in primary tissue culture.

Authors:  W Wang; J H Pizzonia; G B Richerson
Journal:  J Physiol       Date:  1998-09-01       Impact factor: 5.182

5.  Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development.

Authors:  Matthew R Hodges; Mackenzie Wehner; Jason Aungst; Jeffrey C Smith; George B Richerson
Journal:  J Neurosci       Date:  2009-08-19       Impact factor: 6.167

6.  Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo.

Authors:  Eugene E Nattie; Aihua Li; George B Richerson; George Richerson; Douglas A Lappi
Journal:  J Physiol       Date:  2004-01-14       Impact factor: 5.182

7.  Early postnatal administration of 5,7-dihydroxytryptamine: effects on substance P and thyrotropin-releasing hormone neurons and terminals in rat brain.

Authors:  A C Towle; G R Breese; R A Mueller; R Hunt; J M Lauder
Journal:  Brain Res       Date:  1986-01-15       Impact factor: 3.252

Review 8.  Serotonin neurons and central respiratory chemoreception: where are we now?

Authors:  Frida A Teran; Cory A Massey; George B Richerson
Journal:  Prog Brain Res       Date:  2014       Impact factor: 2.453

Review 9.  Medullary serotonin neurons and central CO2 chemoreception.

Authors:  Andrea E Corcoran; Matthew R Hodges; Yuanming Wu; Wengang Wang; Christie J Wylie; Evan S Deneris; George B Richerson
Journal:  Respir Physiol Neurobiol       Date:  2009-04-24       Impact factor: 1.931

Review 10.  Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects.

Authors:  Matthew R Hodges; George B Richerson
Journal:  Respir Physiol Neurobiol       Date:  2008-12-10       Impact factor: 1.931
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