Literature DB >> 64264

Factor VIII coagulant activity and factor VIII-related antigen released from isolated perfused human spleens.

R Pabst, H Heyes, H Rasche, P Schick, F Trepel.   

Abstract

Eight human spleens were perfused for up to 65 h at normothermia and the coagulant Factor VIII activity measured in the perfusate. In addition, in three experiments Factor VIII-related antigen was determined in the perfusate. Although the spleens were pathologically enlarged and the normal structure involved by different diseases, all spleens released Factor VIII coagulant activity and Factor VIII-related antigen. On average the total amount of Factor VIII coagulant activity released was equivalent to that of 3.5 l of human plasma.

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Year:  1977        PMID: 64264     DOI: 10.1007/BF00997035

Source DB:  PubMed          Journal:  Blut        ISSN: 0006-5242


  16 in total

1.  A one-stage factor VIII (antihaemophilic globulin) assay and its use on venous and capillary plasma.

Authors:  R M HARDISTY; J C MACPHERSON
Journal:  Thromb Diath Haemorrh       Date:  1962-05-15

Review 2.  Blood coagulation factor VIII (antihemophilic factor): with comments on von Willebrand's disease and Christmas disease.

Authors:  E M Barrow; J B Graham
Journal:  Physiol Rev       Date:  1974-01       Impact factor: 37.312

3.  Factor 8 on the vascular intima: possible importance in haemostasis and thrombosis.

Authors:  A L Bloom; J C Giddings; C J Wilks
Journal:  Nat New Biol       Date:  1973-02-14

4.  72-hour perfusion of the isolated spleen at normothermia.

Authors:  R Pabst; F Trepel
Journal:  Res Exp Med (Berl)       Date:  1974

5.  Factor VIII-related antigen in tissues detected by the indirect immunofluorescence technique.

Authors:  R Gruson; C R Rizza
Journal:  Blut       Date:  1974-10

6.  Transplantation of the spleen: experimental cure of hemophilia.

Authors:  J C Norman; V H Covelli; H S Sise
Journal:  Surgery       Date:  1968-07       Impact factor: 3.982

7.  Effects of the spleen on canine factor VIII levels.

Authors:  P A McKee; R T Coussons; R G Buckner; G R Williams; J W Hampton
Journal:  J Lab Clin Med       Date:  1970-03

8.  Cell-culture synthesis of a factor VIII-like activity.

Authors:  L R Zacharski; E J Bowie; J L Titus; C A Owen
Journal:  Mayo Clin Proc       Date:  1969-11       Impact factor: 7.616

9.  Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.

Authors:  C B Laurell
Journal:  Anal Biochem       Date:  1966-04       Impact factor: 3.365

10.  Immunologic differentiation of classic hemophilia (factor 8 deficiency) and von Willebrand's dissase, with observations on combined deficiencies of antihemophilic factor and proaccelerin (factor V) and on an acquired circulating anticoagulant against antihemophilic factor.

Authors:  T S Zimmerman; O D Ratnoff; A E Powell
Journal:  J Clin Invest       Date:  1971-01       Impact factor: 14.808

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  1 in total

Review 1.  The pig as a model for immunology research.

Authors:  Reinhard Pabst
Journal:  Cell Tissue Res       Date:  2020-04-30       Impact factor: 5.249

  1 in total

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