| Literature DB >> 6425742 |
M Vergnes, C Marescaux, G Micheletti, A Depaulis, L Rumbach, J M Warter.
Abstract
Certain Wistar rats from our laboratory colony present genetically determined seizures similar to human petit-mal absences. Muscimol, THIP and L-baclofen, agonists of GABA receptors, and gamma-vinyl GABA (GVG), an inhibitor of GABA degradation, enhanced the duration of spontaneous petit-mal-like seizures in a dose-dependent fashion. These findings raise questions as to the role of GABAergic neurotransmission in the occurrence of this type of spontaneous spike and wave discharges.Entities:
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Year: 1984 PMID： 6425742 DOI： 10.1016/0304-3940(84)90226-x
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046