Facilitation of renal function by intermittent mandatory ventilation.

The effects of intermittent mandatory ventilation (IMV) and controlled mechanical ventilation (CMV) on excretory function and the hemodynamics of the kidneys were studied in two groups of anaesthetized dogs during periods of 3 and 4 h. IMV was associated with statistically significant improved urinary output and renal plasma flow of approximately 50 and 35%, respectively. Graphical and statistical analysis revealed certain cross-over effects indicating that the beneficial effect of IMV was more pronounced if it was used following CMV. The improvements in renal function were interpreted as consequences of decreased mean intrathoracic pressures during IMV as compared to CMV. A correlation to global hemodynamic changes could not be established. IMV does facilitate kidney function and hence may successfully counteract the retention of water and salt which occurs during prolonged mechanical ventilation.