Literature DB >> 642414

Nitrofurantoin damages DNA of human cells.

M Hirsch-Kauffmann, P Herrlich, M Schweiger.   

Abstract

Nitrofurantoin causes damage to DNA of cultured diploid human fibroblasts. As a consequence DNA synthesis is blocked. The damage is removed by the normal enzymatic DNA repair system. Xeroderma pigmentosum fibroblasts which are defective in the excision endonuclease fail to repair nitrofurantoin-caused lesions.

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Year:  1978        PMID： 642414     DOI： 10.1007/BF01477295

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  14 in total

Review 1.  Mutagenicity of nitrofuran derivatives, including furylfuramide, a food preservative.

Authors:  Y Tazima; T Kada; A Murakami
Journal:  Mutat Res       Date:  1975       Impact factor: 2.433

2.  Enhancement of radiation response of a murine mammary carcinoma by two nitrofuran derivatives.

Authors:  H B Stone; H R Withers
Journal:  Radiat Res       Date:  1975-12       Impact factor: 2.841

3.  Restoration of ultraviolet-induced unscheduled DNA synthesis of xeroderma pigmentosum cells by the concomitant treatment with bacteriophage T4 endonuclease V and HVJ (Sendai virus).

Authors:  K Tanaka; M Sekiguchi; Y Okada
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

4.  Carcinogenicity of the food additive furylfuramide in foetal and young mice.

Authors:  T Nomura
Journal:  Nature       Date:  1975-12-18       Impact factor: 49.962

Review 5.  DNA-directed enzyme synthesis in vitro.

Authors:  M Schweiger; P Herrlich
Journal:  Curr Top Microbiol Immunol       Date:  1974       Impact factor: 4.291

6.  Messenger-selective inhibitor for the initiation of translation in Escherichia coli: nitrofurantoin.

Authors:  E Wagner; M Schweiger; H Ponta; P Herrlich
Journal:  FEBS Lett       Date:  1977-11-15       Impact factor: 4.124

7.  Production of urinary bladder carcinomas in male hamsters by N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide, N-(4-(5-nitro-2-furyl)-2-thiazolyl)-acetamide, or formic acid 2-(4-(5-nitro-2-furyl)-2-thiazolyl)hydrazide.

Authors:  W A Croft; G T Bryan
Journal:  J Natl Cancer Inst       Date:  1973-09       Impact factor: 13.506

Review 8.  Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion.

Authors:  J McCann; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

9.  Nitrofurans, a group of synthetic antibiotics, with a new mode of action: discrimination of specific messenger RNA classes.

Authors:  P Herrlich; M Schweiger
Journal:  Proc Natl Acad Sci U S A       Date:  1976-10       Impact factor: 11.205

10.  Study on the reinitiation of transcription in 37 RC cells after actinomycin D inhibition. Spectrum of major RNA species resynthesized after maximal suppression by the drug.

Authors:  A Benedetto; C Delfini; G Carloni; W Djaczenko
Journal:  J Cell Biol       Date:  1975-12       Impact factor: 10.539
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