Literature DB >> 6423777

"Therapeutic" serum concentration of phenytoin: the influence of seizure type.

D M Turnbull, M D Rawlins, D Weightman, D W Chadwick.   

Abstract

Serum phenytoin concentrations were monitored prospectively in 26 patients with previously untreated partial epilepsy, during monotherapy with phenytoin. Only six remained entirely seizure-free, although only four experienced further tonic-clonic seizures. There was no correlation between serum phenytoin concentrations and freedom from partial seizures in those patients in whom such seizures recurred. There did appear to be a correlation between serum phenytoin concentration and freedom from tonic-clonic seizures.

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Year:  1984        PMID： 6423777      PMCID： PMC1027719          DOI： 10.1136/jnnp.47.3.231

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  13 in total

1.  Diphenylhydantoin in children. Pharmacology and efficacy.

Authors:  L G Borofsky; S Louis; H Kutt
Journal:  Neurology       Date:  1973-09       Impact factor: 9.910

2.  Studies of anticonvulsant levels in epileptics. I. Serum diphenylhydantoin concentrations in a group of medically indigent outpatients.

Authors:  A F Haerer; J B Grace
Journal:  Acta Neurol Scand       Date:  1969       Impact factor: 3.209

Review 3.  Serum levels of anticonvulsant drugs. Interpretation and clinical value.

Authors:  E H Reynolds
Journal:  Pharmacol Ther       Date:  1980       Impact factor: 12.310

4.  Anticonvulsant effect of diphenylhydantoin relative to plasma levels. A prospective three-year study in ambulant patients with generalized epileptic seizures.

Authors:  L Lund
Journal:  Arch Neurol       Date:  1974-11

5.  Variation in response to anticonvulsants in a group of epileptic patients.

Authors:  R D Travers; E H Reynolds; B B Gallagher
Journal:  Arch Neurol       Date:  1972-07

6.  One drug for epilepsy.

Authors:  S D Shorvon; D Chadwick; A W Galbraith; E H Reynolds
Journal:  Br Med J       Date:  1978-02-25

7.  Phenytoin monotherapy for epilepsy: a long-term prospective study, assisted by serum level monitoring, in previously untreated patients.

Authors:  E H Reynolds; S D Shorvon; A W Galbraith; D Chadwick; C I Dellaportas; L Vydelingum
Journal:  Epilepsia       Date:  1981-08       Impact factor: 5.864

8.  Serum phenytoin concentration and clinical response in patients with epilepsy.

Authors:  D J Gannaway; G E Mawer
Journal:  Br J Clin Pharmacol       Date:  1981-12       Impact factor: 4.335

9.  A comparison of phenytoin and valproate in previously untreated adult epileptic patients.

Authors:  D M Turnbull; M D Rawlins; D Weightman; D W Chadwick
Journal:  J Neurol Neurosurg Psychiatry       Date:  1982-01       Impact factor: 10.154

10.  Single-drug therapy with carbamazepine in patients with epilepsy: serum levels and clinical effect.

Authors:  R E Strandjord; S I Johannessen
Journal:  Epilepsia       Date:  1980-12       Impact factor: 5.864
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  6 in total

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Authors:  D W Chadwick
Journal:  Br Med J (Clin Res Ed)       Date:  1987-03-21

Review 2.  Therapeutic drug monitoring of anticonvulsants. State of the art.

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Review 3.  Concentration-effect relationships of valproic acid.

Authors:  D W Chadwick
Journal:  Clin Pharmacokinet       Date:  1985 Mar-Apr       Impact factor: 6.447

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Journal:  Breast Cancer Res Treat       Date:  2012-06-08       Impact factor: 4.872

5.  Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells.

Authors:  Fatima H Mohammed; Maitham A Khajah; Ming Yang; William J Brackenbury; Yunus A Luqmani
Journal:  Int J Oncol       Date:  2015-11-09       Impact factor: 5.650

Review 6.  Therapeutic Index Estimation of Antiepileptic Drugs: A Systematic Literature Review Approach.

Authors:  Rachel G Greenberg; Chiara Melloni; Huali Wu; Daniel Gonzalez; Lawrence Ku; Kevin D Hill; Christoph P Hornik; Michael Cohen-Wolkowiez; Jeffrey T Guptill
Journal:  Clin Neuropharmacol       Date:  2016 Sep-Oct       Impact factor: 1.379
  6 in total

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