Genetic control of the immune response to haemoglobin. V. Production and characterization of A beta restricted T cell lines and clones.

Monoclonal anti-Ia inhibition experiments were conducted to confirm and extend genetic mapping data of I-A gene control of immunity to human haemoglobin (Hb). It was found that the A beta gene is of critical importance in conferring immunity to the alpha-chain and beta-chain subunits of Hb. A possible involvement of I-E region genes in B10.D2 mice to beta-chain is discussed. Through the use of an alpha-chain specific T cell clone data, is obtained indicating that an intact Ia.8+ A beta chain is necessary for antigen presentation in vitro.