Literature DB >> 6423407

Increase in cytosolic Ca2+ concentration during t-butyl hydroperoxide metabolism by isolated hepatocytes involves NADPH oxidation and mobilization of intracellular Ca2+ stores.

G Bellomo, H Thor, S Orrenius.   

Abstract

Activation of phosphorylase a in hepatocytes incubated with t-butyl hydroperoxide indicates that hydroperoxide metabolism is associated with an increase in cytosolic free Ca2+ concentration which appears to be mediated by NADPH oxidation and to involve mobilization of intracellular Ca2+ stores.

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Year:  1984        PMID： 6423407     DOI： 10.1016/0014-5793(84)80202-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  Oxidized glutathione causes sensitization of calcium release to inositol 1,4,5-trisphosphate in permeabilized hepatocytes.

Authors:  D C Renard; M B Seitz; A P Thomas
Journal:  Biochem J       Date:  1992-06-01       Impact factor: 3.857

2.  Ca-efflux, from direct membrane injury by CCl4, is elicited by amphiphilic vehicles in vitro.

Authors:  J A Fernandez-Lopez; I Subirade; Y Fernandez; P Deltour; A Periquet; S Mitjavila
Journal:  Experientia       Date:  1993-10-15

3.  Biochemical changes in isolated hepatocytes exposed to tert-butyl hydroperoxide. Implications for its cytotoxicity.

Authors:  P Buc-Calderon; I Latour; M Roberfroid
Journal:  Cell Biol Toxicol       Date:  1991-04       Impact factor: 6.691

4.  The possible role of phospholipase A2 in hepatic microsomal lipid peroxidation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats.

Authors:  Z A al-Bayati; S J Stohs
Journal:  Arch Environ Contam Toxicol       Date:  1991-04       Impact factor: 2.804

5.  Detection of peroxyl and alkoxyl radicals produced by reaction of hydroperoxides with rat liver microsomal fractions.

Authors:  M J Davies
Journal:  Biochem J       Date:  1989-01-15       Impact factor: 3.857

6.  Paracetamol toxicity in hamster isolated hepatocytes: the increase in cytosolic calcium accompanies, rather than precedes, loss of viability.

Authors:  S J Hardwick; J W Wilson; D J Fawthrop; A R Boobis; D S Davies
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

7.  Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytes.

Authors:  R Bannach; A Valenzuela; B K Cassels; L J Nunez-Vergara; H Speisky
Journal:  Cell Biol Toxicol       Date:  1996-04       Impact factor: 6.691

Review 8.  The role of calcium ions in toxic cell injury.

Authors:  J L Farber
Journal:  Environ Health Perspect       Date:  1990-03       Impact factor: 9.031

Review 9.  Impact of halogenated compounds on calcium homeostasis in hepatocytes.

Authors:  L Moore; D R Schoenberg; R M Long
Journal:  Environ Health Perspect       Date:  1990-03       Impact factor: 9.031

Review 10.  Mechanisms of cell injury by activated oxygen species.

Authors:  J L Farber
Journal:  Environ Health Perspect       Date:  1994-12       Impact factor: 9.031
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