Literature DB >> 6423405

Depletion of noradrenaline fails to affect kindled seizures.

V Westerberg, J Lewis, M E Corcoran.   

Abstract

Convulsive seizures were kindled in rats by repeated stimulation of the amygdala, and the subjects then received intracerebral injections of 6-hydroxydopamine into the dorsal noradrenergic bundle. Although this treatment severely depleted noradrenaline, there was no effect on the intensity or duration of seizures, suggesting that noradrenaline does not regulate kindled seizures when they have developed.

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Year:  1984        PMID: 6423405     DOI: 10.1016/0014-4886(84)90020-7

Source DB:  PubMed          Journal:  Exp Neurol        ISSN: 0014-4886            Impact factor:   5.330


  3 in total

1.  A point mutation (D79N) of the alpha2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine.

Authors:  S Janumpalli; L S Butler; L B MacMillan; L E Limbird; J O McNamara
Journal:  J Neurosci       Date:  1998-03-15       Impact factor: 6.167

2.  Enhanced susceptibility to kindling by chlordimeform may be mediated by a local anesthetic action.

Authors:  M E Gilbert; C M Mack
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

Review 3.  Physical activity and epilepsy: proven and predicted benefits.

Authors:  Ricardo M Arida; Esper A Cavalheiro; Antonio C da Silva; Fulvio A Scorza
Journal:  Sports Med       Date:  2008       Impact factor: 11.136

  3 in total

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