Literature DB >> 6422950

Novel mode of cytotoxicity obtained by coupling inactive anthracycline to a polymer.

K E Rogers, Z A Tökés.   

Abstract

The inactive anthracycline analog 4-demethoxy-7,9-di-epi-daunorubicin was covalently coupled to polyglutaraldehyde microspheres. The polymer-bound analog acquired significant cytostatic activity as evaluated with doxorubicin resistant and sensitive murine L1210 leukemia cells. A suggested multiple membrane interaction at the cell surface may represent a novel mechanism of cytotoxicity.

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Year:  1984        PMID： 6422950     DOI： 10.1016/0006-2952(84)90315-0

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  7 in total

1.  Is the drug-responsive NADH oxidase of the cancer cell plasma membrane a molecular target for adriamycin?

Authors:  D J Morré; C Kim; M Paulik; D M Morré; W P Faulk
Journal:  J Bioenerg Biomembr       Date:  1997-06       Impact factor: 2.945

2.  Calmodulin and alpha tocopherol as additional binding sites for doxorubicin.

Authors:  R N Nwankwoala; W L West
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

3.  Selectivity of the anthracyclines for negatively charged model membranes: role of the amino group.

Authors:  T G Burke; A C Sartorelli; T R Tritton
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333

4.  Response to adriamycin of transplasma membrane electron transport in adriamycin-resistant and nonresistant HL-60 cells.

Authors:  D J Morré; D M Morré; L Y Wu
Journal:  J Bioenerg Biomembr       Date:  1994-02       Impact factor: 2.945

5.  Cell biological mechanisms of multidrug resistance in tumors.

Authors:  S M Simon; M Schindler
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

6.  An in vivo assessment of adriamycin-loaded albumin microspheres.

Authors:  J A Goldberg; N Willmott; D J Kerr; C Sutherland; C S McArdle
Journal:  Br J Cancer       Date:  1992-03       Impact factor: 7.640

Review 7.  A chemical perspective on the anthracycline antitumor antibiotics.

Authors:  B R Abdella; J Fisher
Journal:  Environ Health Perspect       Date:  1985-12       Impact factor: 9.031
  7 in total

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