Inhibition of the uptake of nucleosides in cultured Harding-Passey melanoma cells by diflubenzuron.

Diflubenzuron (DFB) significantly inhibited the uptake of uridine, adenosine, and cytidine but not thymidine, in cultured Harding-Passey melanoma cells. Inhibition of nucleoside uptake was rapid (i.e., less than or equal to 5 min) and could not be reversed by washing. These results suggest that DFB may affect membrane properties and - as shown by in vivo tests - growth of melanoma cells.