Literature DB >> 6421809

Omega-hydroxylation of 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid in human polymorphonuclear leukocytes.

P Y Wong, P Westlund, M Hamberg, E Granström, P H Chao, B Samuelsson.   

Abstract

Incubation of arachidonic acid or 12-Ls-hydroxy-5,8,10,14-eicosatetraenoic acid with suspensions of human polymorphonuclear leukocytes led to the formation of 12-Ls,20-dihydroxy-5,8,10,14-eicosatetraenoic acid. The structure of the new metabolite was by physical methods and by chemical degradation.

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Year:  1984        PMID： 6421809

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  4 in total

1.  Studies on the mechanism of omega-hydroxylation of platelet 12-hydroxyeicosatetraenoic acid (12-HETE) by unstimulated neutrophils.

Authors:  A J Marcus; L B Safier; H L Ullman; N Islam; M J Broekman; C von Schacky
Journal:  J Clin Invest       Date:  1987-01       Impact factor: 14.808

2.  Erythrocyte-neutrophil interactions: formation of leukotriene B4 by transcellular biosynthesis.

Authors:  J E McGee; F A Fitzpatrick
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

3.  Oxidation of leukotrienes at the omega end: demonstration of a receptor for the 20-hydroxy derivative of leukotriene B4 on human neutrophils and implications for the analysis of leukotriene receptors.

Authors:  R M Clancy; C A Dahinden; T E Hugli
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

4.  Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages.

Authors:  Tamas Kriska; Michael J Thomas; John R Falck; William B Campbell
Journal:  J Lipid Res       Date:  2018-02-22       Impact factor: 5.922
  4 in total

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