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[Presence of a substance immunologically related to somaliberin extracted from human pancreatic tumor (hpGRF) in neurons of the hypophysiotropic area in the guinea-pig and rat].

G Tramu, J C Beauvillain, A Pillez, M Mazzuca.

Abstract

An antiserum raised against the synthetic human pancreatic tumour GRF (hpGRF) made it possible to localize an immunoreactive material in 100 nm granules of nerve terminals distributed in the external layer of the median eminence in Guinea-Pig and Rat. Moreover, especially in colchicine-treated Guinea-Pigs, numerous stained perikarya were observed, exclusively located in the arcuate nucleus. These results suggest that hypothalamic GRF is very similar, if not identical, to hpGRF.

Entities: Chemical Disease Species

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Year: 1983 PMID： 6420015

Source DB: PubMed Journal: C R Seances Acad Sci III ISSN： 0249-6313

[Presence of a substance immunologically related to somaliberin extracted from human pancreatic tumor (hpGRF) in neurons of the hypophysiotropic area in the guinea-pig and rat].

1. Localization of growth hormone-releasing factor-like immunoreactivity in the hypothalamo-hypophysial system of some teleost species.

2. Ultrastructural demonstration of nerve endings containing a substance related to growth hormone-releasing factor in the guinea-pig paraventricular nucleus.

3. Multiple peptide immunoreactivities in the nervous system of Aeschna cyanea (Insecta, Odonata). An immunohistochemical study using antisera to cholecystokinin octapeptide, somatoliberin, vasoactive intestinal peptide, motilin and proctolin.