Literature DB >> 6419985

Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat.

R G Lister, D J Greenblatt, D R Abernethy, S E File.   

Abstract

Methods for determining Ro 15-1788 in brain tissue were developed using gas chromatography with nitrogen-phosphorus detection, and using reverse-phase high performance liquid chromatography. Application of the methods to pharmacokinetic studies in the rat found the elimination half-life of Ro 15-1788 from rat brain to be 16 min. Ro 15-1788 was undetectable in rat plasma at the time points studied. Concentrations of Ro 15-1788 in the brain were reduced if chlordiazepoxide was coadministered.

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Year:  1984        PMID： 6419985     DOI： 10.1016/0006-8993(84)90752-2

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  17 in total

1.  Chronic treatment with Ro 15-1788 distinguishes between its benzodiazepine antagonist, agonist and inverse agonist properties.

Authors:  S E File; J Dingemanse; H L Friedman; D J Greenblatt
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

2.  Acute barbiturate administration increases benzodiazepine receptor binding in vivo.

Authors:  L G Miller; S I Deutsch; D J Greenblatt; S M Paul; R I Shader
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

Review 3.  Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788.

Authors:  S E File; S Pellow
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

4.  A late-appearing benzodiazepine-induced hypoactivity that is not reversed by a receptor antagonist.

Authors:  R G Lister; S E File
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

5.  Stability and pharmacokinetics of flumazenil in the rat.

Authors:  J W Mandema; J M Gubbens-Stibbe; M Danhof
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

6.  Modulation of ethanol withdrawal-induced anxiety-like behavior during later withdrawals by treatment of early withdrawals with benzodiazepine/gamma-aminobutyric acid ligands.

Authors:  Darin J Knapp; David H Overstreet; George R Breese
Journal:  Alcohol Clin Exp Res       Date:  2005-04       Impact factor: 3.455

7.  Ethanol self-administration in freely feeding and drinking rats: effects of Ro15-4513 alone, and in combination with Ro15-1788 (flumazenil).

Authors:  H L June; R W Hughes; H L Spurlock; M J Lewis
Journal:  Psychopharmacology (Berl)       Date:  1994-07       Impact factor: 4.530

8.  Quantitative pharmacological analyses of the interaction between flumazenil and midazolam in monkeys discriminating midazolam: Determination of the functional half life of flumazenil.

Authors:  Claudio Zanettini; Charles P France; Lisa R Gerak
Journal:  Eur J Pharmacol       Date:  2013-11-08       Impact factor: 4.432

9.  Stress-induced changes in respiratory quotient, energy expenditure and locomotor activity in rats: effects of midazolam.

Authors:  I S McGregor; A M Lee; R F Westbrook
Journal:  Psychopharmacology (Berl)       Date:  1994-12       Impact factor: 4.530

10.  On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.

Authors:  S E File; A R Green; D J Nutt; N D Vincent
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530
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