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Literature DB >> 6419760

Serum tocainide enantiomer concentrations in human subjects.

A J Sedman, J Gal, W Mastropaolo, P Johnson, J D Maloney, T P Moyer.

Abstract

Entities: Species

Mesh：

Substances：
Tocainide
Lidocaine

Year: 1984 PMID： 6419760 PMCID： PMC1463303 DOI： 10.1111/j.1365-2125.1984.tb05012.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

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9 in total

1. Suppression of ventricular ectopic depolarizations by tocainide.

Authors: R L Woosley; D G McDevitt; A S Nies; R F Smith; G R Wilkinson; J A Oates
Journal: Circulation Date: 1977-12 Impact factor: 29.690

Review 2. New antiarrhythmic agents: amiodarone, aprindine, disopyramide, ethmozin, mexiletine, tocainide, verapamil.

Authors: D P Zipes; P J Troup
Journal: Am J Cardiol Date: 1978-05-22 Impact factor: 2.778

3. High-performance liquid chromatographic assay for tocainide in human plasma: comparison with gas--liquid chromatographic assay.

Authors: P A Reece; P E Stanley
Journal: J Chromatogr Date: 1980-07-11

4. Efficacy and tolerance of tocainide during acute and long-term treatment of chronic ventricular arrhythmias.

Authors: C Sonnhag
Journal: Eur J Clin Pharmacol Date: 1980-10 Impact factor: 2.953

5. Serum binding of tocainide and its enantiomers in human subjects.

Authors: A J Sedman; D C Bloedow; J Gal
Journal: Res Commun Chem Pathol Pharmacol Date: 1982-10

6. Disposition of (R,S)-tocainide. Some stereoselective aspects.

Authors: J Gal; T A French; T Zysset; P E Haroldsen
Journal: Drug Metab Dispos Date: 1982 Jul-Aug Impact factor: 3.922

7. Long-term tocainide therapy for ventricular arrhythmias.

Authors: R A Winkle; P J Meffin; D C Harrison
Journal: Circulation Date: 1978-05 Impact factor: 29.690

8. Open clinical studies at a referral center: chronic maintenance tocainide therapy in patients with recurrent sustained ventricular tachycardia refractory to conventional antiarrhythmic agents.

Authors: J D Maloney; R G Nissen; J M McColgan
Journal: Am Heart J Date: 1980-12 Impact factor: 4.749

9. New antiarrhythmic agents. 1. Primary alpha-amino anilides.

Authors: E W Byrnes; P D McMaster; E R Smith; M R Blair; R N Boyes; B R Duce; H S Feldman; G H Kronberg; B H Takman; P A Tenthorey
Journal: J Med Chem Date: 1979-10 Impact factor: 7.446

9 in total

7 in total

Serum tocainide enantiomer concentrations in human subjects.

1. Suppression of ventricular ectopic depolarizations by tocainide.

Review 2. New antiarrhythmic agents: amiodarone, aprindine, disopyramide, ethmozin, mexiletine, tocainide, verapamil.

3. High-performance liquid chromatographic assay for tocainide in human plasma: comparison with gas--liquid chromatographic assay.

4. Efficacy and tolerance of tocainide during acute and long-term treatment of chronic ventricular arrhythmias.

5. Serum binding of tocainide and its enantiomers in human subjects.

6. Disposition of (R,S)-tocainide. Some stereoselective aspects.

7. Long-term tocainide therapy for ventricular arrhythmias.

8. Open clinical studies at a referral center: chronic maintenance tocainide therapy in patients with recurrent sustained ventricular tachycardia refractory to conventional antiarrhythmic agents.

9. New antiarrhythmic agents. 1. Primary alpha-amino anilides.

Review 1. Impact of stereoselectivity on the pharmacokinetics and pharmacodynamics of antiarrhythmic drugs.

2. The pharmacokinetics of R- and S-tocainide in patients with acute ventricular arrhythmias.

3. Stereoselective drug disposition: potential for misinterpretation of drug disposition data.

4. Stereoselective pharmacokinetics of tocainide in human uraemic patients and in healthy subjects.

Review 5. Pharmacological importance of stereochemical resolution of enantiomeric drugs.

Review 6. Poisoning due to class 1B antiarrhythmic drugs. Lignocaine, mexiletine and tocainide.

Review 7. Clinical pharmacokinetic considerations in the elderly. An update.