Literature DB >> 6419591

Molecular mechanisms of action of auranofin and other gold complexes as related to their biologic activities.

S T Crooke, C K Mirabelli.   

Abstract

The molecular mechanisms of action of gold complexes in the treatment of rheumatoid arthritis are partially known, as are the mechanisms of action and potential utility of gold complexes in the treatment of neoplastic disease. In this paper, data relative to the mechanism of cytotoxicity and structure activity relationships are presented. Concepts of future research are also discussed.

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Year:  1983        PMID： 6419591     DOI： 10.1016/0002-9343(83)90482-5

Source DB:  PubMed          Journal:  Am J Med        ISSN： 0002-9343            Impact factor:   4.965


  6 in total

1.  Gold-containing indoles as anticancer agents that potentiate the cytotoxic effects of ionizing radiation.

Authors:  Sandra Craig; Lei Gao; Irene Lee; Thomas Gray; Anthony J Berdis
Journal:  J Med Chem       Date:  2012-02-15       Impact factor: 7.446

2.  Effects of auranofin and myochrysine on intestinal transport and morphology in the rat.

Authors:  H V Ammon; S A Fowle; J A Cunningham; R A Komorowski; R F Loeffler
Journal:  Gut       Date:  1987-07       Impact factor: 23.059

Review 3.  Auranofin. A preliminary review of its pharmacological properties and therapeutic use in rheumatoid arthritis.

Authors:  M Chaffman; R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1984-05       Impact factor: 9.546

4.  The tumor proteasome as a novel target for gold(III) complexes: implications for breast cancer therapy.

Authors:  Vesna Milacic; Q Ping Dou
Journal:  Coord Chem Rev       Date:  2009       Impact factor: 22.315

5.  Inhibition of avian myeloblastosis virus reverse transcriptase by aurochloric acid.

Authors:  M Semba; N Tanaka; M Yamada; F Takeuchi; K Matsuta; T Miyamoto; F Hanaoka; M Ui
Journal:  Jpn J Cancer Res       Date:  1990-12

6.  Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections.

Authors:  Liwen Feng; Sébastien Pomel; Perle Latre de Late; Alexandre Taravaud; Philippe M Loiseau; Louis Maes; Fidelis Cho-Ngwa; Christina A Bulman; Chelsea Fischer; Judy A Sakanari; Peter D Ziniel; David L Williams; Elisabeth Davioud-Charvet
Journal:  Molecules       Date:  2020-11-01       Impact factor: 4.411
  6 in total

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