Nature of hepatic damage induced by culture filtrates of seed-borne fungi in the laboratory rat.

Oral intubation of culture filtrates of Aspergillus flavus and A. terreus produced hepatocellular damage in albino rats in the form of perilobular hypertrophy of the parenchymal cells and vacuolar degeneration of cytoplasm. Focal necrosis and early periportal fibrosis were also evident.