| Literature DB >> 641896 |
W G Luttge, T W Jasper, C S Sheets, H E Gray.
Abstract
The steroid 4-androsten-3-one-17beta-carboxylic acid (17betaC) reduced the growth-promoting actions of testosterone, but not those of DHT in accessory sex tissues of castrated mice. The 5alpha-reduction of testosterone to DHT in these tissues was also reduced by 17betaC treatment, suggesting that DHT formation is a required step in the mechanism of action of testosterone.Entities:
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Year: 1978 PMID： 641896 DOI： 10.1530/jrf.0.0530045
Source DB: PubMed Journal: J Reprod Fertil ISSN： 0022-4251