Literature DB >> 6418705

Gilvocarcins, new antitumor antibiotics. 5. Biosynthesis of gilvocarcins: incorporation of 13C-labeled compounds into gilvocarcin aglycones.

K Takahashi, F Tomita.   

Abstract

The biosynthesis of the aglycones of gilvocarcins V and M has been studied with 13C-labeled precursors. The aglycones have been shown to be formed via the acetate pathway and a route for their biosynthesis is proposed which involves secondary addition of an alkyl group.

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Year:  1983        PMID： 6418705     DOI： 10.7164/antibiotics.36.1531

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  10 in total

1.  A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.

Authors:  Eita Sasaki; Yasushi Ogasawara; Hung-Wen Liu
Journal:  J Am Chem Soc       Date:  2010-06-02       Impact factor: 15.419

Review 2.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

3.  The crystal structure and mechanism of an unusual oxidoreductase, GilR, involved in gilvocarcin V biosynthesis.

Authors:  Nicholas Noinaj; Mary A Bosserman; M Alexandra Schickli; Grzegorz Piszczek; Madan K Kharel; Pallab Pahari; Susan K Buchanan; Jürgen Rohr
Journal:  J Biol Chem       Date:  2011-05-10       Impact factor: 5.157

4.  Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters.

Authors:  Madan K Kharel; S Eric Nybo; Micah D Shepherd; Jürgen Rohr
Journal:  Chembiochem       Date:  2010-03-01       Impact factor: 3.164

Review 5.  Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.

Authors:  Madan K Kharel; Jürgen Rohr
Journal:  Curr Opin Chem Biol       Date:  2012-03-30       Impact factor: 8.822

6.  Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis.

Authors:  Pallab Pahari; Madan K Kharel; Micah D Shepherd; Steven G van Lanen; Jürgen Rohr
Journal:  Angew Chem Int Ed Engl       Date:  2011-12-23       Impact factor: 15.336

7.  Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis.

Authors:  Yun-Soo Yeo; S Eric Nybo; Amar G Chittiboyina; Aruna D Weerasooriya; Yan-Hong Wang; Elsa Góngora-Castillo; Brieanne Vaillancourt; C Robin Buell; Dean DellaPenna; Mary Dawn Celiz; A Daniel Jones; Eve Syrkin Wurtele; Nick Ransom; Natalia Dudareva; Khaled A Shaaban; Nidhi Tibrewal; Suman Chandra; Troy Smillie; Ikhlas A Khan; Robert M Coates; David S Watt; Joe Chappell
Journal:  J Biol Chem       Date:  2012-12-14       Impact factor: 5.157

8.  GilR, an unusual lactone-forming enzyme involved in gilvocarcin biosynthesis.

Authors:  Madan Kumar Kharel; Pallab Pahari; Hui Lian; Jürgen Rohr
Journal:  Chembiochem       Date:  2009-05-25       Impact factor: 3.164

9.  The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.

Authors:  Carsten Fischer; Fredilyn Lipata; Jürgen Rohr
Journal:  J Am Chem Soc       Date:  2003-07-02       Impact factor: 15.419

10.  Inactivation of the ketoreductase gilU gene of the gilvocarcin biosynthetic gene cluster yields new analogues with partly improved biological activity.

Authors:  Tao Liu; Madan K Kharel; Lili Zhu; Samuel A Bright; Cynthia Mattingly; Val R Adams; Jürgen Rohr
Journal:  Chembiochem       Date:  2009-01-26       Impact factor: 3.164
  10 in total

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