Literature DB >> 6418621

Action of omeprazole (a benzimidazole derivative) on secretory responses to sham feeding and pentagastrin and upon serum gastrin and pancreatic polypeptide in duodenal ulcer patients.

S J Konturek, N Kweicień, W Obtułowicz, B Kopp, J Oleksy.   

Abstract

The effects of omeprazole, a benzimidazole derivative, have been determined on the secretory responses to modified sham feeding and pentagastrin, and upon serum gastrin and pancreatic polypeptide concentrations in duodenal ulcer patients. Intragastric administration of omeprazole in doses of 2 and 6 mumol/kg produced, respectively, about 50% and 90% reduction in acid outputs in responses to modified sham feeding and pentagastrin without affecting serum gastrin and pancreatic polypeptide response to modified sham feeding.

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Year:  1984        PMID： 6418621      PMCID： PMC1432240          DOI： 10.1136/gut.25.1.14

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  8 in total

1.  Properties of a new class of gastric acid inhibitors.

Authors:  L Olbe; T Berglindh; B Elander; H Helander; E Fellenius; S E Sjöstrand; G Sundell; B Wallmark
Journal:  Scand J Gastroenterol Suppl       Date:  1979

2.  Plasma gastrin concentrations following sham feeding in duodenal ulcer patients.

Authors:  B Stenquist; G Nilsson; J F Rehfeld; L Olbe
Journal:  Scand J Gastroenterol       Date:  1979       Impact factor: 2.423

3.  Effects of substituted benzimidazole (H 149/94) on gastric acid secretion in humans.

Authors:  L Olbe; U Haglund; R Leth; T Lind; C Cederberg; G Ekenved; B Elander; E Fellenius; P Lundborg; B Wallmark
Journal:  Gastroenterology       Date:  1982-07       Impact factor: 22.682

4.  Gastric secretory and plasma hormonal responses to sham-feeding of varying duration in patients with duodenal ulcer.

Authors:  S J Konturek; J Swierczek; N Kwiecień; W Obtutowicz; M Dobrzańska; B Kopp; J Oleksy
Journal:  Gut       Date:  1981-12       Impact factor: 23.059

5.  Effect of glucagon on meal-induced gastric secretion in man.

Authors:  S J Konturek; J Biernat; N Kwiecień; J Oleksy
Journal:  Gastroenterology       Date:  1975-03       Impact factor: 22.682

6.  Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase.

Authors:  E Fellenius; T Berglindh; G Sachs; L Olbe; B Elander; S E Sjöstrand; B Wallmark
Journal:  Nature       Date:  1981-03-12       Impact factor: 49.962

7.  Cephalic phase of pancreatic-polypeptide secretion studied by sham feeding in man.

Authors:  T W Schwartz; B Stenquist; L Olbe
Journal:  Scand J Gastroenterol       Date:  1979       Impact factor: 2.423

8.  Cephalic phase of gastric secretion in healthy subjects and duodenal ulcer patients: role of vagal innervation.

Authors:  S J Konturek; N Kwiecien; W Obtulowicz; E Mikos; E Sito; J Oleksy; T Popiela
Journal:  Gut       Date:  1979-10       Impact factor: 23.059
  8 in total
  10 in total

1.  Effect of single and repeated doses of oral omeprazole on gastric acid and pepsin secretion and fasting serum gastrin and serum pepsinogen I levels.

Authors:  H P Festen; H A Tuynman; J Défize; G Pals; R R Frants; J P Straub; S G Meuwissen
Journal:  Dig Dis Sci       Date:  1986-06       Impact factor: 3.199

2.  Basal, sham feed and pentagastrin stimulated gastric acid, pepsin and electrolytes after omeprazole 20 mg and 40 mg daily.

Authors:  J N Thompson; J A Barr; N Collier; J Spencer; A Bush; L Cope; R J Gribble; J H Baron
Journal:  Gut       Date:  1985-10       Impact factor: 23.059

3.  Influence of chronic omeprazole treatment on gastric endocrine function.

Authors:  H Koop; H Schwarting; A Knorr-Marin; C Willhardt; T Möser; R Arnold
Journal:  Klin Wochenschr       Date:  1987-02-16

4.  Duodenal ulcers that will not heal.

Authors:  R E Pounder
Journal:  Gut       Date:  1984-07       Impact factor: 23.059

5.  Omeprazole induces altered bile acid metabolism.

Authors:  K Shindo; M Machida; M Fukumura; K Koide; R Yamazaki
Journal:  Gut       Date:  1998-02       Impact factor: 23.059

6.  A long lasting gastrin response to apomorphine revealed by inhibitors of gastric acid secretion.

Authors:  M Goiny; K Brodin; C E Elwin; K Uvnäs-Moberg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-07       Impact factor: 3.000

7.  Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole.

Authors:  B K Sharma; I A Santana; E C Wood; R P Walt; M Pereira; P Noone; P L Smith; C L Walters; R E Pounder
Journal:  Br Med J (Clin Res Ed)       Date:  1984-09-22

Review 8.  Omeprazole. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peptic ulcer disease and Zollinger-Ellison syndrome.

Authors:  S P Clissold; D M Campoli-Richards
Journal:  Drugs       Date:  1986-07       Impact factor: 9.546

9.  Action of mifentidine on the secretory response to sham feeding and pentagastrin and on serum gastrin in duodenal ulcer patients.

Authors:  G Bianchi Porro; M Lazzaroni; B P Imbimbo; O Sangaletti; C Ghirardosi; S Daniotti
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

10.  Serum gastrin levels following administration of omeprazole alone or in combination with pirenzepine.

Authors:  A Iwasaki; K Miyazawa; Y Kawamura; Y Sakai; Y Tashiro; K Ito; Y Arakawa; Y Matsuo
Journal:  J Gastroenterol       Date:  1994-08       Impact factor: 7.527
  10 in total

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