Literature DB >> 6418598

Collagen aging in vitro by nonenzymatic glycosylation and browning.

R R Kohn, A Cerami, V M Monnier.   

Abstract

Aging and diabetes mellitus are associated with cross-linking and nonenzymatic glycosylation of collagen. Incubation of tendon fibers with reducing sugars results in increased breaking time in urea similar to that seen in aging, and in nonenzymatic glycosylation and browning. Effect of a sugar is proportional to the amount of sugar available in the open chain form. The increase in breaking time correlates with the appearance of chromophores characteristic of crosslinked browning products. Collagen altered by nonenzymatic browning may play a role in some age-like major complications of diabetes.

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Year:  1984        PMID： 6418598     DOI： 10.2337/diab.33.1.57

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  26 in total

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Authors:  M A Pappolla; J Alzofon; J McMahon; T J Theodoropoulos
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6.  Cardiac dysfunction in aging conscious rats: altered cardiac cytoskeletal proteins as a potential mechanism.

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7.  Effect of glycated collagen on proliferation of human smooth muscle cells in vitro.

Authors:  K Iino; M Yoshinari; M Yamamoto; K Kaku; Y Doi; K Ichikawa; M Iwase; M Fujishima
Journal:  Diabetologia       Date:  1996-07       Impact factor: 10.122

8.  Aminoguanidine treatment reduces the increase in collagen stability of rats with experimental diabetes mellitus.

Authors:  H Oxlund; T T Andreassen
Journal:  Diabetologia       Date:  1992-01       Impact factor: 10.122

9.  Thermal stability of collagen in relation to non-enzymatic glycosylation and browning in vitro.

Authors:  T T Andreassen; H Oxlund
Journal:  Diabetologia       Date:  1985-09       Impact factor: 10.122

10.  Modification of the effect of glycemic status on aortic distensibility by age in the multi-ethnic study of atherosclerosis.

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