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Literature DB >> 6418565

Stimulation of cyclo-oxygenase by lidocaine, a pro-lipoperoxidant.

C Deby, G Deby-Dupont, P Hans, J Pincemail, J Bourdon-Neuray.

Abstract

Lidocaine, which was recently demonstrated to be a good pro-lipoperoxidant, was tested on in vitro PGs biosynthesis, and on arachidonate-induced arterial hypotension, in the rabbit. In the in vitro experiments, lidocaine alone was a poor stimulant of cyclo-oxygenase, but it enhanced significantly the cyclo-oxygenase activation of uric acid. In the rabbit, lidocaine lowered the i.v. arachidonate dose necessary to obtain a significant drop of blood pressure.

Entities: Chemical Disease Species

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Year: 1983 PMID： 6418565 DOI： 10.1007/BF01990106

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

10 in total

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10 in total

Stimulation of cyclo-oxygenase by lidocaine, a pro-lipoperoxidant.

1. Prostaglandin biosynthesis can be triggered by lipid peroxides.

2. Effect of local anesthetics on phospholipases from mitochondria and lysosomes. A probe into the role of the calcium ion in phospholipid hydrolysis.

3. Mechanism for irreversible self-deactivation of prostaglandin synthetase.

4. Correlation between anti-inflammatory properties and inhibition of prostaglandin biosynthesis in vitro.

5. In vitro and in vivo arachidonic acid conversions into biologically active derivatives are enhanced by uric acid.

6. Enhancement of arterial thromboformation by uric acid, a free radical scavenger.

7. Arachidonate induced hypotension and haptoglobin plasma level in the rabbit.

8. The protective effect of lidocaine on arachidonate metabolism in septic shock.

9. The effect of local anesthetics on the hydrolysis of free and membrane-bound phospholipids catalyzed by various phospholipases.

10. Kinetic evidence of a distinct regulatory site on 15-hydroxyprostaglandin dehydrogenase.