Literature DB >> 641809

High-pressure liquid chromatographic analysis of melphalan in plasma.

S Y Chang, D S Alberts, L R Melnick, P D Walson, S E Salmon.   

Abstract

A new sensitive and rapid high-pressure liquid chromatographic determination of melphalan in plasma was developed. Recovery of 1 microgram added to 1 ml of plasma at 23 degrees was 94% but was greatly reduced at higher temperature. The method has been applied to plasma determinations of melphalan in rats and humans and is currently being utilized for human pharmacokinetic studies.

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Year:  1978        PMID： 641809     DOI： 10.1002/jps.2600670529

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  25 in total

Review 1.  Not too little, not too much-just right! (Better ways to give high dose melphalan).

Authors:  P J Shaw; C E Nath; H M Lazarus
Journal:  Bone Marrow Transplant       Date:  2014-08-18       Impact factor: 5.483

2.  Determination of melphalan in human plasma by UPLC-UV method.

Authors:  Liusheng Huang; Vincent Cheah; Danna Chan; Florence Marzan; Christopher C Dvorak; Francesca T Aweeka; Janel Long-Boyle
Journal:  Cancer Chemother Pharmacol       Date:  2019-02-13       Impact factor: 3.333

3.  A sensitive high-performance liquid chromatographic assay for melphalan and its hydrolysis products in blood and plasma.

Authors:  H K Osterheld; E Musch; G E von Unruh; U Loos; H Rauschecker; B J Mühlenbruch
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333

4.  Comparative physico-chemical properties, biological effects, and disposition in mice of four nitrogen mustards.

Authors:  D Godenèche; J C Madelmont; M F Moreau; R Plagne; G Meyniel
Journal:  Cancer Chemother Pharmacol       Date:  1980       Impact factor: 3.333

5.  Pharmacokinetics of high dose melphalan.

Authors:  M R Hersh; T M Ludden; J G Kuhn; W A Knight
Journal:  Invest New Drugs       Date:  1983       Impact factor: 3.850

6.  Metrazol enhances brain penetration and therapeutic efficacy of some anticancer agents: implications for brain metastases.

Authors:  N Greig; D Newell; K Hellmann
Journal:  Clin Exp Metastasis       Date:  1984 Jan-Mar       Impact factor: 5.150

Review 7.  The practical benefits of pharmacokinetics in the use of antineoplastic agents.

Authors:  C Erlichman; R C Donehower; B A Chabner
Journal:  Cancer Chemother Pharmacol       Date:  1980       Impact factor: 3.333

8.  High dose melphalan in children with advanced malignant disease. A pharmacokinetic study.

Authors:  J Ninane; R Baurain; A de Selys; A Trouet; G Cornu
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

9.  Melphalan pharmacokinetics in children with malignant disease: influence of body weight, renal function, carboplatin therapy and total body irradiation.

Authors:  Christa E Nath; Peter J Shaw; Kay Montgomery; John W Earl
Journal:  Br J Clin Pharmacol       Date:  2005-03       Impact factor: 4.335

10.  Comparison of the fed and fasting states on the absorption of melphalan in multiple myeloma.

Authors:  A G Bosanquet; E D Gilby
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333
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