Benzodiazepine-induced thrombocytopenia. Demonstration of drug-dependent platelet antibodies in two cases.

Two cases of benzodiazepine-induced thrombocytopenia are described. Drug-dependent antibodies with antiplatelet activity of the IgG class were detected by inhibition of complement-dependent hemolysis. This technique permitted also the demonstration of cross-reactivity of these antibodies with different benzodiazepines.